{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:19:55Z","timestamp":1785305995666,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,12,11]],"date-time":"2017-12-11T00:00:00Z","timestamp":1512950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.81373934"],"award-info":[{"award-number":["No.81373934"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A target and nontarget strategy based on in\u2010house chemical components library was developed for rapid and comprehensive analysis of complicated components from traditional Chinese medicine preparation Shuang\u2010Huang\u2010Lian oral liquid. The sample was analyzed by ultra\u2010performance liquid chromatography\u2013quadrupole time\u2010of\u2010flight mass spectrometry using generic acquisition parameters. Automated detection and data filtering were performed on the UNIFI\u2122 software and the detected peaks were evaluated against an in\u2010house library. As a result, a total of 170 chemical components (110 target compounds and 60 nontarget ones) were identified or tentatively characterized, including 54 flavonoids, 30 phenylethanoid glycosides, 16 iridoid glycosides, 14 lignans, 32 organic acids, 19 triterpenoid saponins and five other types of compounds. Among them, 44 compounds were further confirmed by comparison with reference standards. It was demonstrated that this systematical approach could be successfully applied for rapid identification of multiple compounds in traditional Chinese medicine and its preparations. Furthermore, this work established the foundation for the further investigation on the metabolic fates of multiple ingredients in Shuang\u2010Huang\u2010Lian oral liquid.<\/jats:p>","DOI":"10.1002\/bmc.4110","type":"journal-article","created":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T11:12:47Z","timestamp":1507547567000},"source":"Crossref","is-referenced-by-count":43,"title":["A target and nontarget strategy for identification or characterization of the chemical ingredients in Chinese herb preparation Shuang\u2010Huang\u2010Lian oral liquid by ultra\u2010performance liquid chromatography\u2013quadrupole time\u2010of\u2010flight mass spectrometry"],"prefix":"10.1002","volume":"32","author":[{"given":"Feng\u2010Xiang","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[{"name":"Hainan Trauma and Disaster Rescue Key Laboratory The First Affiliated Hospital of Hainan Medical College  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010Hong","family":"Yao","sequence":"additional","affiliation":[{"name":"Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry and Natural Medicine Chemistry, College of Pharmacy Harbin Medical University  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Rui","family":"Qiao","sequence":"additional","affiliation":[{"name":"Waters Corporation (Shanghai)  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu\u2010Yu","family":"Shen","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Materia Medica Shenyang Pharmaceutical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Yu","sequence":"additional","affiliation":[{"name":"Waters Corporation (Shanghai)  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4618-1391","authenticated-orcid":false,"given":"Yi","family":"Dai","sequence":"additional","affiliation":[{"name":"Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin\u2010Sheng","family":"Yao","sequence":"additional","affiliation":[{"name":"Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2006.01.060"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2005.02.031"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2014.05.051"},{"key":"e_1_2_7_5_1","volume-title":"Pharmacopoeia of the People's Republic of China","author":"Chinese Pharmacopoeia Commission","year":"2010"},{"issue":"459","key":"e_1_2_7_6_1","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/459508a","article-title":"A change of strategy in the war on cancer","volume":"459","author":"Gatenby R.","year":"2009","journal-title":"Nature"},{"issue":"7378","key":"e_1_2_7_7_1","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1038\/480S87a","article-title":"Perspective: All systems go","volume":"480","author":"Greef J.","year":"2011","journal-title":"Nature"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.2875"},{"key":"e_1_2_7_9_1","first-page":"13","article-title":"A metabolomic strategy to screen the prototype components and metabolites of Shuang\u2010Huang\u2010Lian injection in human serum by ultra\u2010performance liquid chromatography coupled with quadrupole time\u2010of\u2010flight mass spectrometry","volume":"241505","author":"Guo M.","year":"2014","journal-title":"Journal of Analytical Methods in Chemistry"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2007.02.023"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201600784"},{"issue":"1","key":"e_1_2_7_12_1","first-page":"1","article-title":"Quality assurance for Chinese herbal formulae: Standardization of IBS\u201020, a 20\u2010herb preparation","volume":"5","author":"Ip S.","year":"2010","journal-title":"Chinese Medicine"},{"key":"e_1_2_7_13_1","article-title":"Separation and characterization of chemical constituents in Ginkgo Biloba extract by off\u2010line hydrophilic interaction\u00d7reversed\u2010phase two\u2010dimensional liquid chromatography coupled with quadrupole\u2010time of flight mass spectrometry","author":"Ji S.","year":"2017","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"issue":"44","key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.trac.2012.11.006","article-title":"Advances in analytical technologies to evaluate the quality of traditional Chinese medicines","volume":"44","author":"Jing J.","year":"2013","journal-title":"TrAC Trends in Analytical Chemistry"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201500712"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2014.04.010"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0121031"},{"issue":"7","key":"e_1_2_7_18_1","doi-asserted-by":"crossref","first-page":"3799","DOI":"10.14233\/ajchem.2013.13788","article-title":"Structural identification of chemical constituents from Scutellaria Baicalensis by HPLC\u2010ESI\u2010MS\/MS and NMR spectroscopy","volume":"25","author":"Lin W.","year":"2013","journal-title":"Asian Journal of Chemistry"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2009.04.021"},{"issue":"22","key":"e_1_2_7_20_1","first-page":"3357","article-title":"Simultaneous determination of 17 major components of Shuang\u2010\u200bHuang\u2010\u200bLian oral liquid by UPLC\u2010\u200bMS\u200b\/MS","volume":"46","author":"Liu T.","year":"2015","journal-title":"Zhongcaoyao"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2010.08.019"},{"key":"e_1_2_7_22_1","doi-asserted-by":"crossref","first-page":"66\/61","DOI":"10.1186\/s13065-014-0066-z","article-title":"Analyses of chlorogenic acids and related cinnamic acid derivatives from Nicotiana Tabacum tissues with the aid of UPLC\u2010Q\u2010TOF\u2010MS\/MS based on the in\u2010source collision\u2010induced dissociation method","volume":"8","author":"Ncube E.","year":"2014","journal-title":"Chemistry Central Journal"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2009.04.006"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.4245"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2016.02.079"},{"issue":"22","key":"e_1_2_7_26_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.chroma.2012.09.045","article-title":"Novel software\u2010based method to classify structurally similar compounds combined with high performance liquid chromatography\u2013quadrupole time of flight mass spectrometry to identify complex components of herbal medicines","volume":"1264","author":"Shan Q.","year":"2012","journal-title":"Journal of Chromatography A"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2015.06.013"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2017.04.016"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2017.07.031"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201300529"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2014.06.005"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2016.01.047"},{"issue":"4","key":"e_1_2_7_33_1","first-page":"987326","article-title":"Chinese medicine injection shuanghuanglian for treatment of acute upper respiratory tract infection: A systematic review of randomized controlled trials","volume":"2013","author":"Zhang H.","year":"2013","journal-title":"Evidence\u2010based Complementary and Alternative Medicine"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2014.08.025"},{"issue":"1434","key":"e_1_2_7_35_1","first-page":"271","article-title":"Advanced development in chemical analysis of Cordyceps","volume":"87","author":"Zhao J.","year":"2013","journal-title":"Journal of Pharmaceutical and Biomedical Analysis"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/bmv067"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbmc.4110","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.4110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:24:53Z","timestamp":1760041493000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.4110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,11]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["10.1002\/bmc.4110"],"URL":"https:\/\/doi.org\/10.1002\/bmc.4110","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"value":"0269-3879","type":"print"},{"value":"1099-0801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,11]]},"article-number":"e4110"}}