{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:51:04Z","timestamp":1760061064119,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,8]],"date-time":"2017-11-08T00:00:00Z","timestamp":1510099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81274039"],"award-info":[{"award-number":["81274039"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The calyces of <jats:styled-content style=\"fixed-case\"><jats:italic>Physalis alkekengi<\/jats:italic><\/jats:styled-content> var. <jats:italic>franchetii<\/jats:italic> (Chinese Lantern, JDL) are well\u2010known as traditional Chinese medicine owing to its various therapeutic effects. However, the bioactive constituents responsible for the pharmacological effects of JDL and their metabolites <jats:italic>in vivo<\/jats:italic> are still unclear to date. In this paper, an ultra\u2010high\u2010pressure liquid chromatography coupled with quadrupole time\u2010of\u2010flight mass spectrometry (UHPLC\/Q\u2010TOF\u2010MS\/MS) method was established to identify absorbed constituents and <jats:italic>in vivo<\/jats:italic> metabolites in rat biological fluids after oral administration of JDL. Based on the proposed strategy, 33 compounds were observed in dosed rat biosamples. Twelve of 33 compounds were indicated as prototype components of JDL, and 21 compounds were predicted to be metabolites of JDL. Finally, the metabolic pathways were proposed, which were glucuronidation, sulfation, methylation and dehydroxylation for flavonoid constituents and sulfonation and hydroxylation for physalin consitituents. This is the first systematic study on the absorbed constituents and metabolic profiling of JDL and will provide a useful template for screening and characterizing the ingredients and metabolites of traditional Chinese medicine.<\/jats:p>","DOI":"10.1002\/bmc.4121","type":"journal-article","created":{"date-parts":[[2017,10,20]],"date-time":"2017-10-20T23:36:38Z","timestamp":1508542598000},"source":"Crossref","is-referenced-by-count":3,"title":["Identification of absorbed constituents and <i>in vivo<\/i> metabolites in rats after oral administration of <scp><i>Physalis alkekengi<\/i><\/scp> var. <i>franchetii<\/i> by ultra\u2010high\u2010pressure liquid chromatography quadrupole time\u2010of\u2010flight mass spectrometry"],"prefix":"10.1002","volume":"32","author":[{"given":"Xinchi","family":"Feng","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoguang","family":"Huo","sequence":"additional","affiliation":[{"name":"Tianjin State Key Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxia","family":"Liu","sequence":"additional","affiliation":[{"name":"Tianjin State Key Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liwei","family":"Chai","sequence":"additional","affiliation":[{"name":"Tianjin State Key Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqin","family":"Ding","sequence":"additional","affiliation":[{"name":"Tianjin State Key Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5505-8670","authenticated-orcid":false,"given":"Feng","family":"Qiu","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Tianjin University of Traditional Chinese Medicine  Tianjin China"},{"name":"Tianjin State Key Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese Medicine  Tianjin China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,8]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_7_2_1","DOI":"10.1007\/s11101-008-9095-3"},{"doi-asserted-by":"publisher","key":"e_1_2_7_3_1","DOI":"10.2174\/138920021501140218125020"},{"key":"e_1_2_7_4_1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.jchromb.2017.01.037","article-title":"Metabolic profiles of physalin a in rats using ultra\u2010high performance liquid chromatography coupled with quadrupole time\u2010of\u2010flight tandem mass spectrometry","volume":"1046","author":"Feng X.","year":"2017","journal-title":"Journal of Chromatography B"},{"doi-asserted-by":"publisher","key":"e_1_2_7_5_1","DOI":"10.1248\/bpb.34.1584"},{"doi-asserted-by":"publisher","key":"e_1_2_7_6_1","DOI":"10.1124\/dmd.31.8.983"},{"doi-asserted-by":"publisher","key":"e_1_2_7_7_1","DOI":"10.1016\/j.chroma.2014.08.004"},{"doi-asserted-by":"publisher","key":"e_1_2_7_8_1","DOI":"10.1016\/j.steroids.2011.11.016"},{"doi-asserted-by":"publisher","key":"e_1_2_7_9_1","DOI":"10.1007\/s11010-016-2686-1"},{"doi-asserted-by":"publisher","key":"e_1_2_7_10_1","DOI":"10.1002\/bmc.3456"},{"doi-asserted-by":"publisher","key":"e_1_2_7_11_1","DOI":"10.1002\/bmc.1756"},{"doi-asserted-by":"publisher","key":"e_1_2_7_12_1","DOI":"10.2174\/138955709787001712"},{"doi-asserted-by":"publisher","key":"e_1_2_7_13_1","DOI":"10.1211\/jpp.58.2.0011"},{"doi-asserted-by":"publisher","key":"e_1_2_7_14_1","DOI":"10.1016\/j.neuropharm.2014.07.012"},{"issue":"4","key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1021\/np700713r","article-title":"Steroids and flavonoids from Physalis alkekengi Var. Franchetii and their inhibitory effects on nitric oxide production","volume":"71","author":"Qiu L.","year":"2008","journal-title":"Journal of Natural Products"},{"key":"e_1_2_7_16_1","article-title":"Antibacterial and anti\u2010inflammatory activities of Physalis alkekengi var. franchetii and its main constituents","author":"Shu Z.","year":"2016","journal-title":"Evidence\u2010based Complementary and Alternative Medicine"},{"issue":"1","key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1021\/jf980516q","article-title":"Metabolism of 7\u2010fluoro\u20106\u2010(3,4,5,6\u2010tetrahydrophthalimido)\u20104\u2010 (2\u2010propynyl)\u20102H\u20101,4\u2010benzoxazin\u20103(4H)\u2010one (S\u201053482) in rat. 1. 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