{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T21:28:59Z","timestamp":1761514139885,"version":"build-2065373602"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:00:00Z","timestamp":1519257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30873171"],"award-info":[{"award-number":["30873171"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, a liquid chromatography\u2013tandem mass spectrometry (LC\u2010MS\/MS) method was developed and validated to simultaneously determine the anticancer drugs etoposide and paclitaxel in mouse plasma and tissues including liver, kidney, lung, heart, spleen and brain. The analytes were extracted from the matrices of interest by liquid\u2013liquid extraction using methyl <jats:italic>tert<\/jats:italic>\u2010butyl ether\u2013dichloromethane (1:1, v\/v). Chromatographic separation was achieved on an Ultimate XB\u2010C<jats:sub>18<\/jats:sub> column (100 \u00d7 2.1\u2009mm, 3\u2009\u03bcm) at 40\u00b0C and the total run time was 4\u2009min under a gradient elution. Ionization was conducted using electrospray ionization in the positive mode. Stable isotope etoposide\u2010d3 and docetaxel were used as the internal standards. The lower limit of quantitation (LLOQ) of etoposide was 1\u2009ng\/g tissue for all tissues and 0.5\u2009ng\/mL for plasma. The LLOQ of paclitaxel was 0.4\u2009ng\/g tissue and 0.2\u2009ng\/mL for all tissues and plasma, respectively. The coefficients of correlation for all of the analytes in the tissues and plasma were &gt;0.99. Both intra\u2010 and inter\u2010day accuracy and precision were satisfactory. This method was successfully applied to measure plasma and tissue drug concentrations in mice treated with etoposide and paclitaxel\u2010loaded self\u2010microemulsifying drug\u2010delivery systems.<\/jats:p>","DOI":"10.1002\/bmc.4192","type":"journal-article","created":{"date-parts":[[2018,1,19]],"date-time":"2018-01-19T04:47:27Z","timestamp":1516337247000},"source":"Crossref","is-referenced-by-count":4,"title":["Simultaneous LC\u2010MS\/MS bioanalysis of etoposide and paclitaxel in mouse tissues and plasma after oral administration of self\u2010microemulsifying drug\u2010delivery systems"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4075-853X","authenticated-orcid":false,"given":"Dan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pharmacy Shenzhen University Genneral Hospital  Shenzhen Guangdong People' Republic of China"},{"name":"Department of Pharmaceutics, School of Pharmacy, Tongji Medical College Huazhong University of Science and Technology  Wuhan People' Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy, Tongji Medical College Huazhong University of Science and Technology  Wuhan People' Republic of China"},{"name":"Institute of Pharmaceutical Research Jianmin Pharmaceutical Group  Wuhan People' Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weipeng","family":"Ai","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Shenzhen University Genneral Hospital  Shenzhen Guangdong People' Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy, Tongji Medical College Huazhong University of Science and Technology  Wuhan People' Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luqin","family":"Si","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy, Tongji Medical College Huazhong University of Science and Technology  Wuhan People' Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangeng","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy, Tongji Medical College Huazhong University of Science and Technology  Wuhan People' Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunzhou","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan People' Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanlan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan People' Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,2,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2013.10.015"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdd.383"},{"issue":"2","key":"e_1_2_7_4_1","first-page":"153","article-title":"Effect of cyclosporine A on the tissue distribution and pharmacokinetics of etoposide","volume":"54","author":"Carcel\u2010Trullols J.","year":"2004","journal-title":"Cancer Chemotheraphy and Pharmacology"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)00235-8"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-005-0157-6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2017.08.042"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.3989"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.2567"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0936-6555(05)80367-X"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2003.08.049"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2004.09.046"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2005.02.028"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.27912"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.4046"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/5.suppl_4.S3"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.3960"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2016.12.015"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcm.1276"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2011.02.011"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.173"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20249"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djg017"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2006.04.001"},{"issue":"5","key":"e_1_2_7_25_1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.18433\/J3RP6Z","article-title":"A rapid and sensitive HPLC method for quantitation of paclitaxel in biological samples using liquid\u2013liquid extraction and UV detection: Application to pharmacokinetics and tissues distribution study of paclitaxel loaded targeted polymeric micelles in tumor bearing mice","volume":"18","author":"Rezazadeh M.","year":"2015","journal-title":"Journal of Pharmacy & Pharmaceutical Sciences"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/10826076.2011.585483"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2011.01.025"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6603074"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.544"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/80.19.1526"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-014-0238-0"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2005.12.005"},{"volume-title":"Experimental Methodology of Pharmacology","year":"2002","author":"Xu S. Y.","key":"e_1_2_7_33_1"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02976689"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2013.08.016"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.3233"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbmc.4192","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.4192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T20:31:29Z","timestamp":1760041889000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.4192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,22]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1002\/bmc.4192"],"URL":"https:\/\/doi.org\/10.1002\/bmc.4192","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"type":"print","value":"0269-3879"},{"type":"electronic","value":"1099-0801"}],"subject":[],"published":{"date-parts":[[2018,2,22]]},"article-number":"e4192"}}