{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:51:12Z","timestamp":1760061072712,"version":"build-2065373602"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T00:00:00Z","timestamp":1518393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities of China","doi-asserted-by":"crossref","award":["HUST: 2016YXMS141"],"award-info":[{"award-number":["HUST: 2016YXMS141"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Major Program of Science Foundation of Hubei Province","award":["2017ACA165"],"award-info":[{"award-number":["2017ACA165"]}]},{"name":"Grand Project of Science Research for the 12th Five-year Plan","award":["2012ZX09102-101-016"],"award-info":[{"award-number":["2012ZX09102-101-016"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A rapid, robust and sensitive liquid chromatography\u2013tandem mass spectrometry method was developed and validated for bioanalysis of TJ0711, a novel vasodilatory <jats:italic>\u03b2<\/jats:italic>\u2010blocker in dog plasma. This assay is able to chromatographically separate TJ0711 from its isobaric metabolite as well as glucuronide conjugates. Chromatographic separation was achieved on a Welch Ultimate\u2010XB C<jats:sub>18<\/jats:sub> column (2.1 \u00d7 100\u2009mm, 3\u2009\u03bcm). The analyte and internal standard (propranolol) were extracted from plasma by liquid\u2013liquid extraction using ethyl acetate. The mass spectrometric detection was carried out in positive ion multiple reaction monitoring mode. Good linearity was obtained over the concentration range of 0.5\u2013500\u2009ng\/mL (<jats:italic>r<\/jats:italic> &gt; 0.99) for TJ0711. Moreover, the method had good accuracy (RE ranging from \u22122.70 to \u22120.32%) and precision (RSD &lt; 7.55%). TJ0711 was stable in dog plasma for at least 6\u2009h at ambient temperature, for at least 30\u2009days at \u221220\u00b0C and after three freeze\u2013thaw cycles. This method was successfully applied to a preclinical pharmacokinetic study and the results demonstrated linear pharmacokinetics of TJ0711 over a dose range from 0.03 to 0.3\u2009mg\/kg. No significant gender differences were observed in TJ0711 plasma pharmacokinetic parameters.<\/jats:p>","DOI":"10.1002\/bmc.4196","type":"journal-article","created":{"date-parts":[[2018,1,22]],"date-time":"2018-01-22T18:14:06Z","timestamp":1516644846000},"source":"Crossref","is-referenced-by-count":1,"title":["Accurate determination of a novel vasodilatory <i>\u03b2<\/i>\u2010blocker TJ0711 using LC\u2010MS\/MS: Resolution of an isobaric metabolite interference in dog plasma"],"prefix":"10.1002","volume":"32","author":[{"given":"Yang","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0306-3325","authenticated-orcid":false,"given":"Wenwen","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeli","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy, Tongji Medical College Huazhong University of Science and Technology  Wuhan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanlan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Union Hospital, Tongji Medical College Huazhong University of Science and Technology  Wuhan P.R. 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