{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T18:36:24Z","timestamp":1771871784004,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T00:00:00Z","timestamp":1520208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>\u03b2<\/jats:italic>\u2010Thalassemia is one of the most common inherited disorders and is widely distributed throughout the world. Owing to severe deficiencies in red blood cell production, blood transfusion is required to correct anemia for normal growth and development but causes additional complications owing to iron overload. The aim of this study is to quantify the biometal dysregulations in <jats:italic>\u03b2<\/jats:italic>\u2010thalassemia patients as compared with healthy controls. A total of 17 elements were analyzed in serum samples of <jats:italic>\u03b2<\/jats:italic>\u2010thalassemia patients and healthy controls using ICP\u2010MS followed by chemometric analyses. Out of these analyzed elements, 14 showed a significant difference between healthy and disease groups at <jats:italic>p<\/jats:italic> &lt; 0.05 and fold change &gt;3. A PLS\u2010DA model revealed an excellent separation with 89.8% sensitivity and 97.2% specificity and the overall accuracy of the model was 92.2%. This metallomic study revealed that there is major difference in metallomic profiling of <jats:italic>\u03b2<\/jats:italic>\u2010thalassemia patients specifically in Co, Mn, Ni, V and Ba, whereas the fold changes in Co, Mn, V and Ba were found to be greater than that in Fe, providing evidence that, in addition to Fe, other metals are also altered significantly and therefore chelation therapy for other metals may also needed in <jats:italic>\u03b2<\/jats:italic>\u2010thalassemia patients.<\/jats:p>","DOI":"10.1002\/bmc.4200","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T22:32:37Z","timestamp":1517437957000},"source":"Crossref","is-referenced-by-count":1,"title":["Quantitative assessment of metal dysregulation in <i>\u03b2<\/i>\u2010thalassemia patients in comparison with healthy controls by ICP\u2010MS and chemometric analyses"],"prefix":"10.1002","volume":"32","author":[{"given":"Sabiha","family":"Farooq","sequence":"first","affiliation":[{"name":"H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences University of Karachi  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wardah","family":"Mazhar","sequence":"additional","affiliation":[{"name":"H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences University of Karachi  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amna Jabbar","family":"Siddiqui","sequence":"additional","affiliation":[{"name":"H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences University of Karachi  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saqib Hussain","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology and Molecular Medicine National Institute of Blood Diseases and Bone Marrow Transplantation  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2026-3302","authenticated-orcid":false,"given":"Syed Ghulam","family":"Musharraf","sequence":"additional","affiliation":[{"name":"H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences University of Karachi  Karachi Pakistan"},{"name":"Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences University of Karachi  Karachi Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,5]]},"reference":[{"issue":"5","key":"e_1_2_10_2_1","first-page":"377","article-title":"Thalassemia: A current overview","volume":"6","author":"Al\u2010Saqladi A.\u2010W. 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