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The analytes and the internal standard (esomeprazole) were both extracted from plasma samples by liquid\u2013liquid extraction with diethyl ether\u2013dichloromethane (70:30; v\/v). Satisfactory resolution (<jats:italic>R<\/jats:italic><jats:sub>s<\/jats:sub>\u2009=\u20092.0) was achieved within 7.3\u2009min on a Chiralpak ID column (250\u2009\u00d7\u20094.6\u2009mm, 5\u2009\u03bcm) employing acetonitrile\u2013water (60:40, v\/v) as the mobile phase at a flow rate of 0.6\u2009mL\/min. The acquisition of mass spectrometric data was performed in the multiple reaction monitoring mode coupled with a positive electrospray ionization source. A comprehensive validation of this method was rigorously conducted over the concentration range of 1.00\u2013500.0\u2009ng\/mL for both enantiomers. All of the validation data demonstrated that the desirable linearity, sensitivity, accuracy, precision, recovery and stability were attained from the proposed approach. The established method was successfully applied to a stereoselective pharmacokinetic study of lansoprazole enantiomers in rat plasma after oral administration of 3\u2009mg\/kg racemic lansoprazole or dexlansoprazole. No chiral inversion was observed during the experimental procedure.<\/jats:p>","DOI":"10.1002\/bmc.4345","type":"journal-article","created":{"date-parts":[[2018,7,21]],"date-time":"2018-07-21T01:09:47Z","timestamp":1532135387000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Enantioselective analysis of lansoprazole in rat plasma by LC\u2013MS\/MS: Application to a stereoselective pharmacokinetic study"],"prefix":"10.1002","volume":"32","author":[{"given":"Linda","family":"Luo","sequence":"first","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University  Shenyang Liaoning Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Wen","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University  Shenyang Liaoning Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueying","family":"Du","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University  Shenyang Liaoning Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University  Shenyang Liaoning Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7332-4186","authenticated-orcid":false,"given":"Xingjie","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shenyang Pharmaceutical University  Shenyang Liaoning Province People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1998.tb03340.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2016.05.015"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2009.03.021"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.200900590"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2013.07.048"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2005.10.044"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/chir.20701"},{"key":"e_1_2_7_9_1","first-page":"366","article-title":"Dexlansoprazole MR: A review","volume":"43","author":"Hershcovici T.","year":"2011","journal-title":"Annals of Internal Medicine"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.1645"},{"key":"e_1_2_7_11_1","first-page":"535","article-title":"The application of HPCE on the determination of two enantiomers of lansoprazole in human plasma","volume":"29","author":"Jia X.","year":"2012","journal-title":"Journal of Shenyang Pharmaceutical University"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002280100374"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.1560"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEG.S24063"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2010.04.094"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.24.274"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.03984.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-004-0809-1"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2004.01.057"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2015.04.029"},{"key":"e_1_2_7_21_1","first-page":"35","article-title":"Pharmaceutical evaluation of derivative of benzimidazole and improvement of its photostability using polymethylacrylate","volume":"3","author":"Nesseem D. 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