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A rapid procedure has been developed, for the extraction and detection of 19 analytes from the following drug classes: analgesics, benzodiazepines, antidepressants, anticonvulsants and drugs of abuse. These substances are relevant in the context of emergency toxicology in Brazil. The method has been validated according to international guidelines by establishing parameters such as lower limit of quantification, sensitivity, linearity, accuracy and precision. The intra and inter\u2010day precision values, at the lowest concentration levels, have always been less than 20% considering its relative standard deviation. As for accuracy values, these have also been satisfactory (above 81.3%). This method was successfully applied in 201 blood samples from patients with suspected poisoning of the Poison Control Center of S\u00e3o Paulo (PCC\u2010SP), Brazil. Finally, the developed method has shown to be relevant for emergency toxicology due to its high sensitivity and it could be also very useful in both fields of clinical and forensic toxicology.<\/jats:p>","DOI":"10.1002\/bmc.4360","type":"journal-article","created":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T21:04:10Z","timestamp":1534280650000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Development of a simple HPLC\u2010DAD multi\u2010analyte procedure and its application in cases evaluated by the Poison Control Center of S\u00e3o Paulo, Brazil"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2200-6959","authenticated-orcid":false,"given":"Sarah C.W.S.E.","family":"Franco de Oliveira","sequence":"first","affiliation":[{"name":"Faculty of Pharmaceutical Sciences University of Sao Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre D.","family":"Zucoloto","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences University of Sao Paulo  S\u00e3o Paulo SP Brazil"},{"name":"Poison Control Center of Sao Paulo  SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina D.R.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Poison Control Center of Sao Paulo  SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edna M.M.","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Poison Control Center of Sao Paulo  SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ligia V.G.","family":"Fruchtengarten","sequence":"additional","affiliation":[{"name":"Poison Control Center of Sao Paulo  SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiago F.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Federal University of Health Sciences of Porto Alegre  Porto Alegre RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio","family":"Yonamine","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences University of Sao Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.forsciint.2011.10.002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.1797"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.1641"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkt063"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0717-97072010000400009"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/dta.1442"},{"key":"e_1_2_6_8_1","first-page":"28","article-title":"Determination of Drugs in Plasma Samples by High\u2010Performance Liquid Chromatography\u2010Tandem Mass Spectrometry for Therapeutic Drug Monitoring of Schizophrenic Patients","volume":"40","author":"Domingues D. 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