{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T09:27:09Z","timestamp":1778750829039,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T00:00:00Z","timestamp":1539216000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Therapeutic drug monitoring of angiotensin\u2010converting enzyme inhibitors has a great impact on blood pressure control in patients with heart failure and hepatic and renal impairment. To provide an efficient tool for drug assessment in plasma, a UPLC\u2013MS\/MS method was developed for simultaneous determination of benazepril hydrochloride, fosinopril sodium, captopril and hydrochlorothiazide in human plasma samples. Solid phase extraction was applied for sample preparation using OASIS<jats:sup>\u00ae<\/jats:sup> hydrophilic\u2013lipophilic balanced reversed\u2010phase sorbents cartridges. Chromatographic separation was performed using an Agilent SB\u2010C<jats:sub>18<\/jats:sub> column and methanol\u20130.1% formic acid in water (95:5, v\/v) as mobile phase, at flow rate 0.3\u2009mL\/min. Detection was accomplished using a tandem mass spectrometer. The method was validated according to US Food and Drug Administration guidelines. It showed good linearity over concentration ranges 5\u2013400\u2009ng\/mL for benazepril hydrochloride, fosinopril sodium and hydrochlorothiazide and 100\u20133500\u2009ng\/mL for captopril. CV% values were &lt;13.92% whereas the mean accuracy ranged from 94.50 to 113.82% for quality control samples and their extraction recoveries ranged from 90.60 to 99.38%. In conclusion, the present study revealed method selectivity and sensitivity; it can be applied for estimation of angiotensin converting enzyme inhibitors and hydrochlorothiazide in human plasma for dose adjustment and therapeutic drug monitoring.<\/jats:p>","DOI":"10.1002\/bmc.4362","type":"journal-article","created":{"date-parts":[[2018,8,14]],"date-time":"2018-08-14T22:25:48Z","timestamp":1534285548000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Simultaneous ultraperformance liquid chromatography\/tandem mass spectrometry determination of four antihypertensive drugs in human plasma using hydrophilic\u2013lipophilic balanced reversed\u2010phase sorbents sample preparation protocol"],"prefix":"10.1002","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0397-7952","authenticated-orcid":false,"given":"Marianne A.","family":"Mahrouse","sequence":"first","affiliation":[{"name":"Pharmaceutical Chemistry Department, Faculty of Pharmacy Cairo University  Kasr El\u2010Aini St. Cairo 11562 Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0099-5428(04)31003-8"},{"issue":"3","key":"e_1_2_6_3_1","first-page":"80","article-title":"A bioequivalence comparison of two captopril formulations (25 mg tablets): an open\u2010label, randomized, two\u2010treatment, two\u2010way crossover study in healthy volunteers","volume":"6","author":"Chik Z.","year":"2014","journal-title":"Journal of Bioequivalence & Bioavailability"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2007.04.019"},{"key":"e_1_2_6_5_1","unstructured":"DrugBank(n.d.). 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