{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:52:39Z","timestamp":1760061159410,"version":"build-2065373602"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,10,17]],"date-time":"2018-10-17T00:00:00Z","timestamp":1539734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81402190","81403261"],"award-info":[{"award-number":["81402190","81403261"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Kidney stone disease is a worldwide metabolism\u2010associated disorder with a high incidence of renal dysfunction. However, effective methods to prevent crystalline nephropathy are still lacking owing to the absence of aetiological research. Shen\u2019an (SA) capsules are prepared from Chinese medicinal compounds and are considered a promising treatment for the prevention of crystal\u2010induced renal injury. In this study, 24 mice were randomly divided into four groups: saline, oxalate, SA\u2010treated (via preventive administration) and SA\u2010only groups. A metabolomics analysis based on ultra\u2010high\u2010performance liquid chromatography coupled with quadrupole time\u2010of\u2010flight mass spectrometry (UPLC\u2010Q\u2010TOF\/MS) was performed to explore the plasma metabolic profiles among the different groups. The amount of crystal deposition and the decline in kidney function were significantly alleviated by the use of SA capsule. A total of 24 metabolites that showed a reversal trend following SA capsule administration were identified as plasma biomarkerss of the preventive effects of SA capsules on crystal\u2010induced renal injury. Most of these metabolites were involved in the metabolisms of lipid metabolism, energy metabolism, glutathione metabolism and vitamin metabolism. In conclusion, SA capsules exert a preventive effect in mice with crystal\u2010induced kidney injury via the regulation of multiple metabolic pathways.<\/jats:p>","DOI":"10.1002\/bmc.4374","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T20:45:48Z","timestamp":1535057148000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The mechanism of the preventive effect of Shen\u2019an capsule on the calcium oxalate crystal\u2010induced early renal injury based on metabolomics"],"prefix":"10.1002","volume":"32","author":[{"given":"Wei","family":"Fan","sequence":"first","affiliation":[{"name":"No. 425 Hospital of PLA  Sanya China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2269-4029","authenticated-orcid":false,"given":"Jiebin","family":"Hou","sequence":"additional","affiliation":[{"name":"Changhai Hospital Second Military Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiye","family":"Zhu","sequence":"additional","affiliation":[{"name":"Changhai Hospital Second Military Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Cadets Brigade Second Military Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keda","family":"Shao","sequence":"additional","affiliation":[{"name":"Cadets Brigade Second Military Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feiyu","family":"Quan","sequence":"additional","affiliation":[{"name":"No. 425 Hospital of PLA  Sanya China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Changhai Hospital Second Military Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.10.002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04960513"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016030306"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2017.10.013"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0261-5614(03)00128-6"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.03.025"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2004.11.029"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2016.08.014"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aju.2012.04.005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00240-008-0143-7"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.01.002"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000355751"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.19.8970"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.3792"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22060925"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2017.04.001"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i52"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2017.10"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-014-0658-5"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00240-007-0082-8"},{"issue":"3","key":"e_1_2_8_22_1","first-page":"2680","article-title":"Inhalation of hydrogen gas ameliorates glyoxylate\u2010induced calcium oxalate deposition and renal oxidative stress in mice","volume":"8","author":"Peng Z.","year":"2015","journal-title":"International Journal of Clinical and Experimental Pathology"},{"issue":"7","key":"e_1_2_8_23_1","first-page":"650","article-title":"Effect of combined therapy of xiaoke shen\u2019an capsule and western medicine in diabetic nephropathy","volume":"25","author":"Piao C. 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