{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T15:49:40Z","timestamp":1788623380531,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T00:00:00Z","timestamp":1540166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81530095"],"award-info":[{"award-number":["No. 81530095"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Salvia miltiorrhiza<\/jats:italic>, one of the most well\u2010known herbal medicines, is commonly used for the treatment of coronary heart diseases in China. Besides traditional decoction slices (TDS), another relatively new product of <jats:italic>S. miltiorrhiza<\/jats:italic>, ultrafine granular powder (UGP; D90\u2009&lt;\u200945\u2009\u03bcm), is also increasingly being used. In this paper, a UHPLC\u2010LTQ\u2010Orbitrap MS technique was developed for a metabolite profile study after oral administration of UGP and TDS of <jats:italic>S. miltiorrhiza<\/jats:italic>. The results showed that the number of <jats:italic>in vivo<\/jats:italic> absorbed compounds from UGP was much greater than that from TDS, and different types of products from <jats:italic>S. miltiorrhiza<\/jats:italic> will have different metabolic processes <jats:italic>in vivo<\/jats:italic>. Furthermore, a UHPLC\u2010Q\u2010Trap MS\/MS method for simultaneously determining four tanshinones (tanshinone IIA, dihydrotanshinone I, tanshinone I and cryptotanshinone) was established and applied to assess the pharmacokinetics of the two types of products. All of the analytes displayed significant higher area under the concentration\u2013time curve and peak concentration after oral administration of UGP than after TDS, indicating that ultrafine powder product could improve the bioavailability and absorption of cryptotanshinon,tanshinone II A,dihydrotanshinonE I and tanshinone I <jats:italic>in vivo<\/jats:italic>. The present study provides scientific information for further exploration of the pharmacology of these two types of <jats:italic>S. miltiorrhiza<\/jats:italic> and offers a reference for clinical administration of <jats:italic>S. miltiorrhiza<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/bmc.4385","type":"journal-article","created":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T05:33:02Z","timestamp":1537594382000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Comparative <i>in vivo<\/i> constituents and pharmacokinetic study in rats after oral administration of ultrafine granular powder and traditional decoction slices of Chinese <i>Salvia<\/i>"],"prefix":"10.1002","volume":"33","author":[{"given":"Haijuan","family":"Zhi","sequence":"first","affiliation":[{"name":"Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology Shanghai Institute of Materia Medica, Chinese Academy of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenwei","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology Shanghai Institute of Materia Medica, Chinese Academy of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Deng","sequence":"additional","affiliation":[{"name":"Shanghai Research Center for Modernization of Traditional Chinese Medicine, National Engineering Laboratory for TCM Standardization Technology Shanghai Institute of Materia Medica, Chinese Academy of Sciences  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Qi","sequence":"additional","affiliation":[{"name":"Shanghai Research Center for Modernization of Traditional 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