{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T21:58:25Z","timestamp":1786571905194,"version":"build-2736575974"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T00:00:00Z","timestamp":1544054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["No. LY17H280002"],"award-info":[{"award-number":["No. LY17H280002"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LY17H280002"],"award-info":[{"award-number":["LY17H280002"]}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hongjingtian injection is made from <jats:italic>Rhodiola wallichiana<\/jats:italic> and used in the treatment of stable angina pectoris associated with coronary heart disease. In this study, the chemical constituents in Hongjingtian injection were comprehensively studied using liquid chromatography quadrupole time\u2010of\u2010flight mass spectrometry. A total of 49 compounds were identified or assumed, including 10 organic acids, nine phenylethanoids, 10 phenylpropanoids, two flavonoid glycosides, seven monoterpene glycosides, seven octylglycosides and four other types of compounds. The structures of seven compounds were confirmed by comparing their retention times, MS and UV spectra with the corresponding authentic standards. Amongst the 49 compounds, 35 were firstly found in <jats:italic>R. wallichiana<\/jats:italic>, while they have been reported in other species of the genus <jats:italic>Rhodiola<\/jats:italic>, including <jats:italic>Rhodiola crenulata<\/jats:italic>, <jats:italic>Rhodiola sacra<\/jats:italic>, <jats:styled-content style=\"fixed-case\"><jats:italic>Rhodiola rosea<\/jats:italic><\/jats:styled-content> and <jats:italic>Rhodiola kirilowii<\/jats:italic>. The possible fragmentation pathways in the mass spectrometry of the major types of compounds are proposed and summarized. Our study demonstrates a rapid method for characterizing the chemical constituents present in the Hongjingtian injection, which could also be applied to the identification of chemical constituents in other TCM formulae containing <jats:italic>R. wallichiana<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/bmc.4446","type":"journal-article","created":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T07:14:55Z","timestamp":1542957295000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Characterization of the chemical constituents in Hongjingtian injection by liquid chromatography quadrupole time\u2010of\u2010flight mass spectrometry"],"prefix":"10.1002","volume":"33","author":[{"given":"Yining","family":"Liu","sequence":"first","affiliation":[{"name":"College of Pharmaceutical Sciences Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Canhui","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiuwen","family":"Qiu","sequence":"additional","affiliation":[{"name":"Tonghua Yusheng Pharmaceutical Co. Ltd  Tonghua China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongbao","family":"Fang","sequence":"additional","affiliation":[{"name":"Tonghua Yusheng Pharmaceutical Co. Ltd  Tonghua China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Wu","sequence":"additional","affiliation":[{"name":"Tonghua Yusheng Pharmaceutical Co. Ltd  Tonghua China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxian","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0715-0525","authenticated-orcid":false,"given":"Shufang","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,6]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"258","article-title":"Anti\u2010tumor metastatic constituents from Rhodiola wallichiana","volume":"40","author":"Chai Y. Q.","year":"2015","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.04.011"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.22.157"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3746\/pnf.2015.20.1.38"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00580087"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.3887"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.25.1101"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.56.536"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2017.1335724"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1365\/s10337-004-0415-5"},{"key":"e_1_2_6_12_1","first-page":"56","article-title":"Effect and mechanism of Sofren injection in the treatment of stable angina petoris","volume":"34","author":"Wang H. Y.","year":"2017","journal-title":"Zhong Yi Yao Xin Xi"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2014.04.084"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep31000"},{"key":"e_1_2_6_15_1","first-page":"2822","article-title":"Chemical constituents from rhizomes of Rhodiola wallichiana var. cholaensis and their protective effects on myocardium","volume":"47","author":"Wang X. J.","year":"2016","journal-title":"Zhong Cao Yao"},{"key":"e_1_2_6_16_1","first-page":"3471","article-title":"Chemical constituents from Rhodiola wallichiana var. cholaensis (I)","volume":"46","author":"Wang X. J.","year":"2015","journal-title":"Zhong Cao Yao"},{"key":"e_1_2_6_17_1","first-page":"308","article-title":"Phytochemical and analytical studies of extracts from Rhodiola rosea and Rhodiola quadrifida","volume":"62","author":"Wiedenfeld H.","year":"2007","journal-title":"Pharmazie"},{"key":"e_1_2_6_18_1","first-page":"164","article-title":"Study on fingerprint of Hongjingtian injection by HPLC","volume":"22","author":"Yang S. Y.","year":"2016","journal-title":"Tianjin Yi Ke Da Xue Xue Bao"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf204660c"},{"key":"e_1_2_6_20_1","first-page":"916","article-title":"Study on fingerprint of Dazhu hongjingtian injection","volume":"25","author":"Yao L. W.","year":"2011","journal-title":"Zhongguo Yao Shi"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6965739"},{"key":"e_1_2_6_22_1","first-page":"1001","article-title":"The effect of Hongjingtian (Gadol) injection on cardiac hemodynamics and myocardial oxygen consumption of dogs","volume":"30","author":"Zhang Z. H.","year":"2005","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"e_1_2_6_23_1","first-page":"119","article-title":"Studies on chemical constituents from Rhodiola wallichiana","volume":"22","author":"Zhao N.","year":"2016","journal-title":"Tianjin Yi Ke Da Xue Xue Bao"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1034288"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbmc.4446","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.4446","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bmc.4446","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.4446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T19:59:39Z","timestamp":1760039979000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.4446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,6]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1002\/bmc.4446"],"URL":"https:\/\/doi.org\/10.1002\/bmc.4446","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"value":"0269-3879","type":"print"},{"value":"1099-0801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,6]]},"assertion":[{"value":"2018-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e4446"}}