{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T03:18:19Z","timestamp":1768015099548,"version":"3.49.0"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T00:00:00Z","timestamp":1548028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573603"],"award-info":[{"award-number":["81573603"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20161047"],"award-info":[{"award-number":["BK20161047"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20161047"],"award-info":[{"award-number":["BK20161047"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["KYCX18_1611"],"award-info":[{"award-number":["KYCX18_1611"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004863","name":"Zhejiang Chinese Medical University","doi-asserted-by":"publisher","award":["Ya2017003"],"award-info":[{"award-number":["Ya2017003"]}],"id":[{"id":"10.13039\/501100004863","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Xanthii fructus<\/jats:italic> (XF), the fruit of <jats:italic>Xanthium sibiricum Patr<\/jats:italic>., is a traditional Chinese materia medica commonly used to treat allergic rhinitis and other rhinitis diseases. To uncover the mechanism of the stir\u2010frying process and its effect on the pharmacokinetic behavior of active compounds in model rats, four active compounds\u2014chlorogenic acid, 4\u2010caffeoylquinic acid, 1,5<jats:italic>\u2010O\u2010<\/jats:italic>dicaffeoylquinic acid and apigenin\u2014were selected based on previous spectrum\u2010effect experiments. High performance liquid chromatography tandem triple quadrupole mass spectrometry (UPLC\u2013QqQ\u2013MS) technology, an accurate and feasible method, was applied to measure the concentration of these four compounds in rat plasma. This validated method can accurately measure the concentration of each compound at each sampling point of rat plasma. This validated method shows good linearity, extraction recoveries, matrix effects, intra\u2010 and inter\u2010day precision and stabilities. Compared with the XF group, the maximum plasma concentration (<jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub>) value of 1,5<jats:italic>\u2010O\u2010<\/jats:italic>dicaffeoylquinic acid decreased remarkably (<jats:italic>p<\/jats:italic> &lt; 0.05) after oral administration of stir\u2010fried <jats:italic>Xanthii fructus<\/jats:italic> (SXF) extract, while the other compounds showed no significant difference. The mean residence time value of chlorogenic acid (<jats:italic>p<\/jats:italic> &lt; 0.05) and 1,5<jats:italic>\u2010O\u2010<\/jats:italic>dicaffeoylquinic acid (<jats:italic>p<\/jats:italic>&lt;0.01) after oral administration of SXF extraction demonstrated significant differences compared with the XF group, while the other two compounds showed no statistical difference, indicating that the stir\u2010frying process prolonged the effect time and delayed the removal time of chlorogenic acid and 1,5<jats:italic>\u2010O\u2010<\/jats:italic>dicaffeoylquinic acid. The values of the area under the plasma concentration\u2013time curve from zero to the last quantifiable time\u2010point, the area under the plasma concentration\u2013time curve from zero to infinity, the time to maximum concentration and the elimination half\u2010life of four compounds in the SXF group showed no statistically significant difference from the XF group. From this data, we speculated that the stir\u2010frying process can not only keep the absorption of 4\u2010caffeoylquinic acid and apigenin, but also increase the effect time of chlorogenic acid and 1,5<jats:italic>\u2010O\u2010<\/jats:italic>dicaffeoylquinic acid, which could be the mechanism underlying the stir\u2010frying process enhancing the effects of XF.<\/jats:p>","DOI":"10.1002\/bmc.4464","type":"journal-article","created":{"date-parts":[[2018,12,9]],"date-time":"2018-12-09T21:13:27Z","timestamp":1544390007000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Ultra\u2010high\u2010performance liquid chromatography with tandem mass spectrometry method for determination of four compounds in rat plasma after oral administration of <i>Xanthii fructus<\/i> and stir\u2010fried <i>Xanthii fructus<\/i> extracts"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6146-7902","authenticated-orcid":false,"given":"Yanshuang","family":"Zhuang","sequence":"first","affiliation":[{"name":"Engineering Center of State Ministry of Education for Chinese Medicine Processing Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunming","family":"Qin","sequence":"additional","affiliation":[{"name":"Nanjing Haichang Chinese Medicine Group Co., Ltd.  Nanjing China"},{"name":"Nanjing Haiyuan Prepared Slices of Chinese Crude Drugs Co. Ltd  Nanjing China"},{"name":"Huaihai Institute of Technology  Lianyu Gang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Liu","sequence":"additional","affiliation":[{"name":"Engineering Center of State Ministry of Education for Chinese Medicine Processing Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baochang","family":"Cai","sequence":"additional","affiliation":[{"name":"Engineering Center of State Ministry of Education for Chinese Medicine Processing Nanjing University of Chinese Medicine  Nanjing China"},{"name":"Nanjing Haichang Chinese Medicine Group Co., Ltd.  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Cai","sequence":"additional","affiliation":[{"name":"Engineering Center of State Ministry of Education for Chinese Medicine Processing Nanjing University of Chinese Medicine  Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3736\/jcim20060217"},{"issue":"3","key":"e_1_2_7_3_1","first-page":"270","article-title":"Thoughts and experimental exploration on pharmacokinetic study of herbal medicines with multiple\u2010components and targets","volume":"44","author":"Hao","year":"2012","journal-title":"Acta Pharmaceutica Sinica"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.5740\/jaoacint.11-032"},{"issue":"12","key":"e_1_2_7_5_1","first-page":"1213","article-title":"Influence of processing on the content of toxic carboxyatractyloside and atractyloside and the microbiological status of Xanthium sibiricum fruits (Cang\u02bcerzi)","volume":"81","author":"Nikles S.","year":"2015","journal-title":"Planta Medica"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201400874"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2006.11.036"},{"key":"e_1_2_7_8_1","unstructured":"Shen J. 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