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A novel LC\/MS method was developed and validated for determination of olanzapine in schizophrenia patients' plasma. A liquid\u2013liquid extraction procedure was carried out using 5\u2009mL diethyl ether\u2013diisopropyl ether mixture (1:1, v\/v). Average recovery of the extraction procedure was 94.8%. Chromatographic separation was performed on reversed\u2010phase C<jats:sub>18<\/jats:sub> column (250\u2009\u00d7\u20092.0\u2009mm, 5\u2009\u03bcm) using mixture of deionized water (trifluoro acetic acid 0.1%)\u2013acetonitrile (20:80, v\/v) as mobile phase at a flow rate of 1\u2009mL\/min. Irbesartan was used as internal standart and total run time was 2.5\u2009min. Mass spectrometric analysis were carried out in selective\u2010ion montoring mode, and detected olanzapine at <jats:italic>m<\/jats:italic>\/<jats:italic>z<\/jats:italic> 313.1 and IS at <jats:italic>m<\/jats:italic>\/<jats:italic>z<\/jats:italic> 429.4 in all forms of the ions. The calibration curve of olanzapine was linear in the range 2\u2013300\u2009ng\/mL (<jats:italic>r<\/jats:italic><jats:sup>2<\/jats:sup>\u2009&gt;\u20090.9993). The interday and intraday precisions (RSD) were &lt;7.55%, and accuracy was &gt;7.59% (<jats:italic>n<\/jats:italic>\u2009=\u20096). The proposed study was successfully validated with respect to the US Food and Drug Administration guidelines.<\/jats:p>","DOI":"10.1002\/bmc.4468","type":"journal-article","created":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T21:49:06Z","timestamp":1544737746000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Determination of olanzapine for therapeutic drug monitoring in schizophrenia patients by LC\/MS method"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8673-6577","authenticated-orcid":false,"given":"Mevlut","family":"Albayrak","sequence":"first","affiliation":[{"name":"Department of Medical Laboratory Techniques, Health Services Vocational Training School Ataturk University  Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yucel","family":"Kadioglu","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Pharmacy Ataturk University  Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet Emrah","family":"Yaman","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Pharmacy Ataturk University  Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Onur","family":"Senol","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Pharmacy Ataturk University  Erzurum Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif","family":"Oral","sequence":"additional","affiliation":[{"name":"Department of Psychiatry \u0130zmir Katip \u00c7elebi University, Ataturk Training and Research Hospital  \u0130zmir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,1,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2012.12.071"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199706000-00011"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/070674370304801102"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0893-133X(95)00069-P"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(01)00548-5"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(01)00240-7"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.59.5.441"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199937030-00001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.2174\/157341212801619351"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12353"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2009.07.007"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-012-6695-y"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ftd.0000211800.66569.c9"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199753020-00007"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-012-5802-4"},{"issue":"2","key":"e_1_2_7_17_1","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1176\/ajp.156.2.286","article-title":"Clinical and theoretical implications of 5\u2010HT2 and D\u20102 receptor occupancy of clozapine, risperidone, and olanzapine in schizophrenia","volume":"156","author":"Kapur S.","year":"2014","journal-title":"American Journal of Psychiatry"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2006.05.031"},{"key":"e_1_2_7_19_1","first-page":"759","article-title":"A high\u2010performance liquid chromatography with electrochemical detection for the determination of olanzapine in human plasma","volume":"65","author":"Kobyli\u0144ska K.","year":"2008","journal-title":"Acta Poloniae Pharmaceutica. 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