{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:33:13Z","timestamp":1762144393590,"version":"build-2065373602"},"reference-count":12,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T00:00:00Z","timestamp":1117584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A rapid and reliable high\u2010performance liquid chromatographic method was developed and validated for the simultaneous determination of norephedrine (NE), norpseudoephedrine (NPE), ephedrine (E), pseudoephedrine (PE), methylephedrine (ME) and methylpseudoephedrine (MPE) in both a Mahwang traditional Chinese medicine (TCM) preparation and in urine using <jats:italic>\u03b1<\/jats:italic>\u2010ethylbenzylamine as the internal standard. The method uses a Spherisorb C<jats:sub>18<\/jats:sub> column for an isocratic elution in a tetraethylammoniumphosphate\u2010methanol mobile phase at a wavelength of 206 nm. The limits of detection of NE, NPE, E, PE, ME and MPE in sample solutions ranged from 0.1 to 0.3 \u00b5g[sol ]mL at a signal\u2010to\u2010noise ratio of 3. The within\u2010day precision as calculated from the Mahwang TCM preparation and urine samples was below 6.2 and 1.4% for each analyte. The between\u2010day precision as calculated from the Mahwang TCM preparation and urine samples was below 6.8 and 5.9% for each analyte. The between\u2010day accuracy as determined from the Mahwang TCM preparation and urine samples was below 2.2 and 6.8% for each analyte. The recoveries for six compounds, obtained with compounds spiked into the Mahwang TCM preparation and urine, were found to be more than 93.6%. This method can be successfully applied to doping and excretion rate studies. Copyright \u00a9 2005 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.452","type":"journal-article","created":{"date-parts":[[2005,6,1]],"date-time":"2005-06-01T08:46:30Z","timestamp":1117615590000},"page":"337-342","source":"Crossref","is-referenced-by-count":11,"title":["Simultaneous quantification of six ephedrines in a Mahwang preparation and in urine by high\u2010performance liquid chromatography"],"prefix":"10.1002","volume":"19","author":[{"given":"Kuei Hui","family":"Chan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryh\u2010Nan","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei\u2010Chich","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"60","article-title":"Commonly practiced quality control and quality assurance procedures for gas chromatography\/mass spectrometry analysis in forensic urine drug\u2010testing laboratories","volume":"9","author":"Goldberger BA","year":"1997","journal-title":"Forensic Science Review"},{"doi-asserted-by":"publisher","key":"e_1_2_1_3_1","DOI":"10.1021\/js9801844"},{"doi-asserted-by":"publisher","key":"e_1_2_1_4_1","DOI":"10.1016\/0021-9673(93)80522-A"},{"doi-asserted-by":"publisher","key":"e_1_2_1_5_1","DOI":"10.1016\/S0021-9673(99)00903-6"},{"volume-title":"The OMAC 1999 Olympic Movement Anti\u2010Doping Code","year":"2001","author":"IOC.","key":"e_1_2_1_6_1"},{"doi-asserted-by":"publisher","key":"e_1_2_1_7_1","DOI":"10.1016\/S0731-7085(99)00065-5"},{"doi-asserted-by":"publisher","key":"e_1_2_1_8_1","DOI":"10.1248\/cpb.31.2359"},{"doi-asserted-by":"publisher","key":"e_1_2_1_9_1","DOI":"10.1006\/phrs.2002.0954"},{"key":"e_1_2_1_10_1","first-page":"607","volume-title":"Applied Biopharmaceutics and Pharmacokinetics","author":"Shargel L","year":"1999"},{"doi-asserted-by":"publisher","key":"e_1_2_1_11_1","DOI":"10.1016\/0378-4347(94)00360-2"},{"issue":"1","key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0022-3565(25)28008-9","article-title":"Absorption, metabolism and excretion of the ephedrines in man. 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