{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:15:26Z","timestamp":1790997326606,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T00:00:00Z","timestamp":1562112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A well\u2010known analgesic (paracetamol, PAR) and skeletal muscle relaxant [dantrolene sodium (DNS)] have been analyzed without interference from their toxic impurities and degradation products. The studied PAR impurities are the genotoxic and nephrotoxic <jats:italic>p<\/jats:italic>\u2010amino phenol (PAP) and the hepatotoxic and nephrotoxic chloroacetanilide, while 5\u2010(4\u2010nitrophenyl)\u20102\u2010furaldehyde is reported to be a mutagenic and carcinogenic degradation product of DNS. The five studied components were determined and quantified by TLC\u2013densitometric and RP\u2010HPLC methods. TLC\u2013densitometry (method 1) used TLC silica gel and chloroform\u2013ethyl acetate\u2013acetic acid\u2013triethylamine (7:3:0.5:0.05, by volume) as the mobile phase with UV scanning at 230\u2009nm, while RP\u2010HPLC (method 2) was based on separation on a C<jats:sub>18<\/jats:sub> column using methanol\u2013water (55:45, v\/v pH\u20093 with aqueous formic acid) as mobile phase at 1\u2009mL\/min and detection at 230\u2009nm. The developed methods were used for determination and quantification of the five studied components in different laboratory\u2010prepared mixtures. The were also applied for analysis of Dantrelax<jats:sup>\u00ae<\/jats:sup> compound capsules where no interference among the studied components with each other or from excipients was observed. The methods were validated as per International Conference on Harmonization guidelines, and they compared favorably with the reported ones.<\/jats:p>","DOI":"10.1002\/bmc.4598","type":"journal-article","created":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T17:59:06Z","timestamp":1558375146000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Different stability\u2010indicating chromatographic methods for specific determination of paracetamol, dantrolene sodium, their toxic impurities and degradation products"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0700-7542","authenticated-orcid":false,"given":"Nada S.","family":"Abdelwahab","sequence":"first","affiliation":[{"name":"Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Beni\u2010Suef University  Beni\u2010Suef Egypt"},{"name":"Pharmaceutical Chemistry, Faculty of Pharmacy Nahda University  Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3784-1332","authenticated-orcid":false,"given":"Maha M.","family":"Abdelrahman","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Beni\u2010Suef University  Beni\u2010Suef Egypt"},{"name":"Pharmaceutical Chemistry, Faculty of Pharmacy Nahda University  Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1881-9749","authenticated-orcid":false,"given":"John M.","family":"Boshra","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry, Faculty of Pharmacy Nahda University  Beni\u2010Suef Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed A.","family":"Taha","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry, Faculty of Pharmacy Ain shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2AY26085A"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2015.04.043"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1556\/1006.2016.29.6.9"},{"key":"e_1_2_6_5_1","first-page":"167","article-title":"Rapid and simultaneous determination of acetylsalicylic acid, paracetamol, and their degradation and toxic impurity products by HPLC in pharmaceutical dosage forms","volume":"38","author":"Akay C.","year":"2008","journal-title":"Turkish Journal of Medical Sciences"},{"key":"e_1_2_6_6_1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1093\/jaoac\/90.1.82","article-title":"Simultaneous determination of paracetamol, chlorzoxazone, and related impurities 4\u2010aminophenol, 4\u2010chloroacetanilide, and p\u2010chlorophenol in pharmaceutical preparations by high\u2010performance liquid chromatography","volume":"90","author":"Ali M. 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