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Ten\u2010milligram hair samples were decontaminated, pulverized using a ball mill, extracted with 1\u2009mL of methanol spiked with 28 deuterated internal standards in an ultrasonic bath for 60\u2009min at 50\u00b0C, and purified with Q\u2010sep dispersive solid\u2010phase extraction tubes. The purified extracts were evaporated to dryness and the residue was dissolved in 0.1\u2009mL of 10% methanol. The 75 analytes were analyzed on an Acquity HSS T3 column using gradient elution of methanol and 0.1% formic acid and quantified in multiple reaction monitoring mode with positive electrospray ionization. Calibration curves were linear (<jats:italic>r<\/jats:italic>\u2009\u2265\u20090.9951) from the lower limit of quantitation (2\u2013200\u2009pg\/mg depending on the drug) to 2000\u2009pg\/mg. The coefficients of variation and accuracy for intra\u2010 and inter\u2010assay analysis at three QC levels were 4.3\u201312.9% and 89.2\u2013109.1%, respectively. The overall mean recovery ranged from 87.1 to 105.3%. This method was successfully applied to the analysis of 11 forensic hair samples obtained from drug abusers.<\/jats:p>","DOI":"10.1002\/bmc.4600","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T11:25:17Z","timestamp":1558524317000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Simultaneous determination of 75 abuse drugs including amphetamines, benzodiazepines, cocaine, opioids, piperazines, zolpidem and metabolites in human hair samples using liquid chromatography\u2013tandem mass spectrometry"],"prefix":"10.1002","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5942-7154","authenticated-orcid":false,"given":"Yongho","family":"Shin","sequence":"first","affiliation":[{"name":"BK21 PLUS Team for Creative Leader Program for Pharmacomics\u2010based Future Pharmacy and Drug Metabolism and Bioanalysis Laboratory, College of Pharmacy The Catholic University of 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