{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:56:43Z","timestamp":1760061403053,"version":"build-2065373602"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,1,14]],"date-time":"2005-01-14T00:00:00Z","timestamp":1105660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An attempt to create and study an arti\ufb01cial membrane system was realized via biopartitioning micellar liquid chromatography. Towards this end the known formula of membrane permeability (on the basis of Fick's diffusion equation) was modi\ufb01ed so that membrane permeability may be estimated in terms of chromatographic characteristics. The two\u2010factoral experiments on the basis of mathematical design of second order were carried out. The regression equations are derived which describe the dependence of membrane permeability on the concentration of polyoxyethylene (23) lauryl ether in the mobile phase and its \ufb02ow\u2010rate for compounds with biomedical signi\ufb01cance. Some regularities were revealed, which characterize the permeability of compounds of the different nature through membranes. The extremal dependence (with passing through minimum) of permeability on the concentration of non\u2010ionic surfactant was observed for anionic compounds. The increasing character of permeability in relation with \ufb02ow\u2010rate of mobile phase was recognized for cationic samples. Both dependences were basically ful\ufb01lled for zwitterionic compounds. Copyright \u00a9 2005 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.469","type":"journal-article","created":{"date-parts":[[2005,1,14]],"date-time":"2005-01-14T12:00:01Z","timestamp":1105704001000},"page":"169-177","source":"Crossref","is-referenced-by-count":4,"title":["Investigation of arti\ufb01cial biomembrane systems in biopartitioning micellar chromatography by method of mathematical design"],"prefix":"10.1002","volume":"19","author":[{"given":"Marina D.","family":"Rukhadze","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George S.","family":"Bezarashvili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya G.","family":"Kutkhashvili","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kethevan I.","family":"Sigua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,14]]},"reference":[{"volume-title":"Metody Optimizatsii Experimenta","year":"1985","author":"Akhnazarova SI","key":"e_1_2_1_2_1"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac00188a011"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(98)00163-7"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-7439(98)00065-3"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(01)00124-4"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)00546-6"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(95)00837-3"},{"key":"e_1_2_1_9_1","first-page":"275","volume-title":"Biophysical Chemistry","author":"Pasinsky AG","year":"1963"},{"key":"e_1_2_1_10_1","first-page":"2226","article-title":"I and Sarajishvili TG. Effect of Brij\u201035 micelle\u2010forming reagent on the retention of sorbates in high\u2010performance liquid chromatography","volume":"77","author":"Rukhadze MD","year":"2003","journal-title":"Russian Journal of Physical Chemistry"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(97)00961-8"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbmc.469","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.469","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T19:04:29Z","timestamp":1760036669000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.469"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1,14]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["10.1002\/bmc.469"],"URL":"https:\/\/doi.org\/10.1002\/bmc.469","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"type":"print","value":"0269-3879"},{"type":"electronic","value":"1099-0801"}],"subject":[],"published":{"date-parts":[[2005,1,14]]}}}