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The pathological development of AD is closely related to lipid metabolism disorders. To reveal the influence of Kai\u2010Xin\u2010San (KXS) on lipid metabolism in APP\/PSI transgenic mice and potential therapeutic targets for treating AD, brain tissue samples were collected and analyzed by high\u2010throughput lipidomics based on UPLC\u2013Q\/TOF\u2010MS. The collected raw data were processed by multivariate data analysis to discover the potential biomarkers and lipid metabolic profiles. Compared with the control wild\u2010type mouse group, nine potential lipid biomarkers were found in the AD model group, of which seven were up\u2010regulated and two were down\u2010regulated. Orally administrated KXS can reverse the changes in these potential biomarkers. Compared with the model group, a total of six differential metabolites showed a recovery trend and may be potential targets for KXS to treat AD. This study showed that high\u2010throughput lipidomics can be used to discover the perturbed pathways and lipid biomarkers as potential targets to reveal the therapeutic effects of KXS.<\/jats:p>","DOI":"10.1002\/bmc.4724","type":"journal-article","created":{"date-parts":[[2019,11,22]],"date-time":"2019-11-22T02:51:15Z","timestamp":1574391075000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["High\u2010throughput lipidomics analysis to discover lipid biomarkers and profiles as potential targets for evaluating efficacy of Kai\u2010Xin\u2010San against APP\/PS1 transgenic mice based on UPLC\u2013Q\/TOF\u2013MS"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3784-4472","authenticated-orcid":false,"given":"Ai\u2010hua","family":"Zhang","sequence":"first","affiliation":[{"name":"National Chinmedomics Research Center, Sino\u2010America Chinmedomics Technology Collaboration Center, 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