{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T07:46:16Z","timestamp":1762674376985,"version":"build-2065373602"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,3,28]],"date-time":"2020-03-28T00:00:00Z","timestamp":1585353600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473364","81,473,364"],"award-info":[{"award-number":["81473364","81,473,364"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Qu\u2010feng\u2010sheng\u2010shi Granules (QFSSG), a common prescription for the treatment of chronic inflammation and allergic rhinitis, is widely used in the clinic as a traditional Chinese medicine. Chemical analysis and quality control studies of this formulation are relatively limited compared with pharmacological studies. In this study, a high\u2010performance liquid chromatography coupled with electrospray ionization quadrupole time\u2010of\u2010flight tandem mass spectrometry (HPLC\u2013ESI\u2013Q\/TOF\u2013MS<jats:sup><jats:italic>n<\/jats:italic><\/jats:sup>) was used to identify the components in this prescription. Next, to quantify six major compounds, an HPLC\u2013UV method was developed and validated. The results showed that 53 compounds were identified based on the MS<jats:sup><jats:italic>n<\/jats:italic><\/jats:sup> data, retention time and previous reports, including 17 coumarins, 14 lignans, 10 chromones, nine phenylethanoid glycosides and three other compounds, were identified or tentatively assigned. Contents of six major bioactive compounds (4\u2032\u2010<jats:italic>O<\/jats:italic>\u2010<jats:italic>\u03b2<\/jats:italic>\u2010glucopyranosyl\u20105\u2010<jats:italic>O<\/jats:italic>\u2010methylvisamminol, Prim\u2010<jats:italic>O<\/jats:italic>\u2010glucosylcimifugin, forsythin, magnolin, imperatorin, isoimperatorin) could be determined by HPLC simultaneously. In addition, the potential anti\u2010inflammatory activity of six major compounds was determined too, and we found that four compounds (4\u2032\u2010<jats:italic>O<\/jats:italic>\u2010<jats:italic>\u03b2<\/jats:italic>\u2010glucopyranosyl\u20105\u2010<jats:italic>O<\/jats:italic>\u2010methylvisamminol, Prim\u2010<jats:italic>O<\/jats:italic>\u2010glucosylcimifugin, forsythin, imperatorin) have a potent nitric oxide inhibitory effect. In conclusion, this work provided comprehensive information on the quality control of QFSSG and evaluated the potential biological activity of the main components in QFSSG, which can contribute to understanding and using it more scientifically.<\/jats:p>","DOI":"10.1002\/bmc.4829","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T23:38:41Z","timestamp":1584142721000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Analysis of chemical constituents and six compounds in Qu\u2010feng\u2010sheng\u2010shi Granules via HPLC\u2013ESI\u2013Q\/TOF\u2013MS<sup><i>n<\/i><\/sup> and HPLC\u2013UV technique"],"prefix":"10.1002","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0703-839X","authenticated-orcid":false,"given":"Pengshuo","family":"Yang","sequence":"first","affiliation":[{"name":"College of Life Sciences Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruilin","family":"Gao","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyao","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Life Sciences Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingsong","family":"Qu","sequence":"additional","affiliation":[{"name":"College of Life Sciences Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyuan","family":"Shi","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing China"},{"name":"Key Laboratory for Production Process Control and Quality Evaluation of Traditional Chinese Medicine Beijing Municipal Science and Technology Commission  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zenglin","family":"Lian","sequence":"additional","affiliation":[{"name":"Yizhuang Economic Development Zone Beijing Yichuang Biotechnology Industry Research Institute  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,28]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"518","article-title":"Quantification of rutin in rat's brain by UHPLC\/ESI\u2013Q\u2010TOF\u2013MS\/MS after intranasal administration of rutin loaded chitosan nanoparticles","volume":"15","author":"Ahmad N.","year":"2016","journal-title":"EXCLI Journal"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2017.1366482"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.112.6_Supplement.321S"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(11)60010-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11094-014-1017-7"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(15)30071-6"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/08923973.2012.736522"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.14.94"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1298433"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.118"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.01.010"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2008.03.010"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.2496"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2012.01.083"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/asia.200800354"},{"issue":"11","key":"e_1_2_6_17_1","first-page":"1014","article-title":"Experimental study on anti\u2010inflammatory and anti\u2010allergic effects of magnolin","volume":"33","author":"Li X. 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