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It is a chiral substance and is used in therapy in the form of the enantiopure <jats:italic>S<\/jats:italic>\u2010DLX, which is twice as active as <jats:italic>R<\/jats:italic>\u2010DLX. Several methods have been published for the achiral and chiral determination of DLX in pharmaceuticals, biological materials and environmental samples, the majority using liquid chromatography and capillary electrophoresis coupled with different detection techniques (UV detection, fluorescence, mass spectrometry). The aim of the current review is to provide a systematic survey of the analytical techniques used for the determination of DLX from different matrices.<\/jats:p>","DOI":"10.1002\/bmc.4883","type":"journal-article","created":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T18:11:23Z","timestamp":1589307083000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Achiral and chiral analysis of duloxetine by chromatographic and electrophoretic methods, a review on the separation methodologies"],"prefix":"10.1002","volume":"35","author":[{"given":"Daniela","family":"Lupu","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy University of Medicine, Pharmacy Science and Technology of T\u00e2rgu Mure\u015f  T\u00e2rgu Mure\u015f Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2564-9271","authenticated-orcid":false,"given":"Gabriel","family":"Hancu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy University of Medicine, Pharmacy Science and Technology of T\u00e2rgu Mure\u015f  T\u00e2rgu Mure\u015f Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,3]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/30.8.576"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AJP.0000000000000471"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612053764805"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.2895"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/elps.200900343"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2010.09.017"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfda.2018.07.003"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/10826076.2011.578322"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-018-3664-y"},{"key":"e_1_2_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2012.09.004"},{"key":"e_1_2_3_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/10401230701333319"},{"key":"e_1_2_3_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/10826079608005497"},{"key":"e_1_2_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2014.05.059"},{"key":"e_1_2_3_15_1","doi-asserted-by":"publisher","DOI":"10.2165\/11539240-000000000-00000"},{"key":"e_1_2_3_16_1","first-page":"1","article-title":"Monoamine's role in depression and possible consequences for the clinical management of the core symptoms of major depression","volume":"44","author":"La Pia S.","year":"2009","journal-title":"Rivista di Psichiatria"},{"key":"e_1_2_3_17_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.31.9.1142"},{"key":"e_1_2_3_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetasy.2016.09.007"},{"key":"e_1_2_3_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(98)00295-7"},{"key":"e_1_2_3_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2007.01.018"},{"key":"e_1_2_3_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2005.08.010"},{"key":"e_1_2_3_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00772"},{"key":"e_1_2_3_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2009.02.059"},{"key":"e_1_2_3_24_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.0208e04"},{"key":"e_1_2_3_25_1","unstructured":"Q3B Impurities in new drug products In: International Conference on Harmonization. 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