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In this study, a rapid and accurate ultra\u2010high\u2010pressure liquid chromatography coupled with diode array detector (UHPLC\u2013DAD) method was developed and validated for the simultaneous determination of nine absorbed compounds of RMC\/PMC. After extraction by protein precipitation with methanol from plasma, the analytes were separated on an Acquity UPLC\u00ae BEH Shield RP<jats:sub>18<\/jats:sub> column (2.1\u2009\u00d7\u2009100\u2009mm, 1.7\u2009\u03bcm, Waters, USA). Acetonitrile (A) and 0.1% (v\/v) formic acid in water (B) were selected as the mobile phase to perform gradient elution. The linearity of nine analytes was &gt;0.9915. The intra\u2010 and inter\u2010assay precision (RSD) values were within 11.18%, and accuracy ranged from 91.32 to 101.29%. Suitable stability, matrix effect and extraction recoveries were also obtained. The validated method was applied to compare the pharmacokinetics of RMC and PMC in Blood\u2010Heat and Hemorrhage Syndrome Model and normal rats. The results revealed that processing and the pathological state could influence the pharmacokinetic characteristics of compounds in RMC\/PMC. The study willbe useful for further studies on pharmacokinetics and clinical application of raw and processed Moutan Cortex.<\/jats:p>","DOI":"10.1002\/bmc.4963","type":"journal-article","created":{"date-parts":[[2020,8,13]],"date-time":"2020-08-13T05:58:47Z","timestamp":1597298327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Nine absorbed components pharmacokinetic of raw and processed Moutan Cortex in normal and blood\u2010heat and hemorrhage syndrome model rats"],"prefix":"10.1002","volume":"34","author":[{"given":"Qiuli","family":"Ye","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine, Guangdong Pharmaceutical University\/Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica State Administration of Traditional Chinese Medicine\/Engineering Technology Research Center for Chinese Materia Medica Quality of Universities in Guangdong Province  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Guangdong Pharmaceutical University\/Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica State Administration of Traditional Chinese Medicine\/Engineering Technology Research Center for Chinese Materia Medica Quality of Universities in Guangdong Province  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donghui","family":"Yan","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Guangdong Pharmaceutical University\/Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica State Administration of Traditional Chinese Medicine\/Engineering Technology Research Center for Chinese Materia Medica Quality of Universities in Guangdong Province  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Guangdong Pharmaceutical University\/Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica State Administration of Traditional Chinese Medicine\/Engineering Technology Research Center for Chinese Materia Medica Quality of Universities in Guangdong Province  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Pharmacy Jinan University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Cao","sequence":"additional","affiliation":[{"name":"College of Pharmacy Jinan University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shumei","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Guangdong Pharmaceutical University\/Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica State Administration of Traditional Chinese Medicine\/Engineering Technology Research Center for Chinese Materia Medica Quality of Universities in Guangdong Province  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6821-0897","authenticated-orcid":false,"given":"Jiang","family":"Meng","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Guangdong Pharmaceutical University\/Key Laboratory of Digital Quality Evaluation of Chinese Materia Medica State Administration of Traditional Chinese Medicine\/Engineering Technology Research Center for Chinese Materia Medica Quality of Universities in Guangdong Province  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"154","article-title":"Advances in research on hemostatic components of traditional Chinese medicine","volume":"8","author":"Bao B. 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