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In this study, we conducted the comparative pharmacokinetic analysis of seven main bioactive components of SM\u2010MC in a different model rat. A straightforward ultra\u2010performance liquid chromatography\u2013tandem mass spectrometry (UPLC\u2010MS\/MS) strategy that could simultaneously evaluate the levels of seven compounds was used to ensure the reliability of these pharmacokinetic analyses in rat plasma. The rat plasma samples were collected from normal, sham\u2010operated, and myocardial ischemia\u2013reperfusion injury (MIRI) groups at predetermined time points after the administration of SM\u2010MC. The main pharmacokinetic parameters were detected and calculated. We successfully assessed the maximum concentration (<jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub>), time to <jats:italic>C<\/jats:italic><jats:sub>max<\/jats:sub> (<jats:italic>T<\/jats:italic><jats:sub>max<\/jats:sub>), the elimination rate constant (<jats:italic>\u03bb<\/jats:italic><jats:sub>z<\/jats:sub>), total half\u2010life (<jats:italic>t<\/jats:italic><jats:sub>1\/2<\/jats:sub>), total body clearance (CL), and the area under the concentration\u2013time curve from 0 to last sampling time (AUC<jats:sub>0\u2013<jats:italic>t<\/jats:italic><\/jats:sub>) and extrapolated to infinity (AUC<jats:sub>0\u2013\u221e<\/jats:sub>). To sum up, an optimized UPLC\u2010MS\/MS approach that could be used to rapidly, simultaneously, and sensitively detect seven bioactive compounds derived from SM\u2010MC extract preparations was successfully developed, which may offer a pharmacokinetic basis for preclinical and clinical studies of SM\u2010MC herb pair for treating MIRI.<\/jats:p>","DOI":"10.1002\/bmc.5016","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T16:34:50Z","timestamp":1604075690000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparative pharmacokinetics of seven bioactive components in normal, sham\u2010operated, and myocardial ischemia\u2013reperfusion injury rats after oral administration of the Salvia Miltiorrhiza\u2013Moutan Cortex herb pair"],"prefix":"10.1002","volume":"35","author":[{"given":"Haotian","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Hebei Province General Center National Clinical Drug Monitoring Center  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Hebei Province General Center National Clinical Drug Monitoring Center  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaojun","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Hebei Province General Center National Clinical Drug Monitoring Center  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caihui","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Hebei Province General Center National Clinical Drug Monitoring Center  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4367-1202","authenticated-orcid":false,"given":"Zhanjun","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Hebei Province General Center National Clinical Drug Monitoring Center  Shijiazhuang China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(02)00011-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00862.2003"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320350303"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-0879fje"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2010.05.024"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2012.07.015"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.752618"},{"issue":"8","key":"e_1_2_8_9_1","first-page":"1535","article-title":"Effect of puerarin in Longmaining formula on pharmacokinetics\u2010pharmacodynamics correlation in rats with myocardial ischemia","volume":"41","author":"Dong L. 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