{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T15:29:15Z","timestamp":1760887755458,"version":"build-2065373602"},"reference-count":40,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,7,21]],"date-time":"2005-07-21T00:00:00Z","timestamp":1121904000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>When they were independently tested, the enantiomers of <jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2032\u2010bis(salicylidene)\u2010<jats:italic>trans<\/jats:italic>\u20101,2\u2010cyclohexanediamine showed a large difference in adsorption on new chiral selectors using microbatch technology. Surprisingly, when these enantiomers were applied on the same supports as a racemic mixture, no discrimination was observed even though suitable adsorption existed. When a mixture enriched in one enantiomer (scalemic mixture) was applied, the resulting supernatant contained the racemic form and the enantiomer in excess was adsorbed on the support together with a part of racemate. This behavior, which militates in favor of a strong heterochiral dimer formation in the racemate, was revealed using microbatch technology but remained hidden on classical column chromatography on chiral support. Molecular dynamics calculations corroborate this hypothesis, showing a favorite binding mode of the heterochiral dimer, which is stabilized by various inter\u2010 and intramolecular interactions. Our findings may be considered as a new limitation of microbatch technology, but they may have some inference in case of chiral amplification using the <jats:italic>N<\/jats:italic>,<jats:italic>N<\/jats:italic>\u2032\u2010bis(salicylidene)\u2010<jats:italic>trans<\/jats:italic>\u20101,2\u2010cyclohexanediamine enantiomers as chiral ligands. Copyright \u00a9 2005 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.502","type":"journal-article","created":{"date-parts":[[2005,7,21]],"date-time":"2005-07-21T12:07:17Z","timestamp":1121947637000},"page":"434-438","source":"Crossref","is-referenced-by-count":15,"title":["Enantiorecognition on solid chiral selectors using microbatch technology: an example of limitation in case of strong association in the racemate"],"prefix":"10.1002","volume":"19","author":[{"given":"Christian","family":"Roussel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esfandiar","family":"Rafii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto Del","family":"Rio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Vanthuyne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,7,21]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.540160708"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00205a001"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0957-4166(97)00375-3"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)01366-8"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2003.10.071"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0957-4166(96)00083-3"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac000568q"},{"key":"e_1_2_1_9_1","first-page":"72","article-title":"Atropisomerism in some N,N\u2032\u2010diaryl\u20102\u2010iminothiazoline derivatives: chiral separation and configuration stability","author":"Bouchekara M","year":"2002","journal-title":"Arkivoc"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0957-4166(03)00128-9"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(01)87863-8"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jo00081a015"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac00144a043"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-3773(19981116)37:21<2922::AID-ANIE2922>3.0.CO;2-1"},{"key":"e_1_2_1_15_1","first-page":"855","article-title":"Optically active complexes of Schiff bases. 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