{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:52:55Z","timestamp":1792104775870,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,23]],"date-time":"2020-11-23T00:00:00Z","timestamp":1606089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603283 and U1504828"],"award-info":[{"award-number":["81603283 and U1504828"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>Bidens bipinnata<\/jats:italic><\/jats:styled-content> L. is a folk medicinal plant in China that shows significant antihyperlipidemia effectiveness. However, studies of the underlying mechanism study are lacking. In order to explore the potential action sites and the underlying mechanism of treating hyperlipidemic, this work undertook tissue distribution and molecular docking research on the markers of <jats:styled-content style=\"fixed-case\"><jats:italic>B. bipinnata<\/jats:italic><\/jats:styled-content> L., which were obtained through serum pharmacochemistry and network database retrieval. The results showed that seven compounds (gallic acid, protocatechuic acid, rutin, hyperoside, bipinnate polyacetylenicloside, luteolin and quercetin) were screened out as markers. Owing to the diversity of chemical structures, they exhibited an inconsistent trend in tissue distribution. However, all of them had high levels in the liver and no specific distribution in other tissues. More interestingly, seven proteins\u2014HMGCR (1HWK), NR3C1 (4P6W), CYP1A2 (2HI4), RXRA (4PP3), CES1 (1MX1), HSD11B1 (2RBE) and CYP1A1 (4I8V)\u2014showed significant binding affinity with three or more markers, suggesting that they may be the target proteins of <jats:styled-content style=\"fixed-case\"><jats:italic>B. bipinnata<\/jats:italic><\/jats:styled-content> L. This study preliminarily sheds light on the tissue distribution and targets of <jats:styled-content style=\"fixed-case\"><jats:italic>B. bipinnata<\/jats:italic><\/jats:styled-content> L., providing some useful information on the underlying mechanisms of the antihyperlipidemia effect.<\/jats:p>","DOI":"10.1002\/bmc.5026","type":"journal-article","created":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T23:00:15Z","timestamp":1604962815000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Tissue distribution and molecular docking research on the active components of <scp><i>Bidens bipinnata<\/i><\/scp> L. against hyperlipidemia"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4443-1844","authenticated-orcid":false,"given":"Guo","family":"Zhuang","sequence":"first","affiliation":[{"name":"Scientific Research Center Nanyang Medical College  Nanyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Qing","family":"Wang","sequence":"additional","affiliation":[{"name":"Scientific Research Center Nanyang Medical College  Nanyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9561-0949","authenticated-orcid":false,"given":"Shu\u2010Jiao","family":"Li","sequence":"additional","affiliation":[{"name":"Scientific Research Center Nanyang Medical College  Nanyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Scientific Research Center Nanyang Medical College  Nanyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Scientific Research Center Nanyang Medical College  Nanyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S158554"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2003.10.036"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.2012.01480.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-019-0474-2"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.03.047"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1132"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11655-008-0071-y"},{"key":"e_1_2_7_9_1","unstructured":"FDA. 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