{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T21:46:02Z","timestamp":1761428762240,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,7,21]],"date-time":"2005-07-21T00:00:00Z","timestamp":1121904000000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dimethyl\u2010<jats:italic>\u03b2<\/jats:italic>\u2010cyclodextrin (DM\u2010<jats:italic>\u03b2<\/jats:italic>\u2010CD) modified capillary electrophoresis has been developed for chiral separation of ephedrine and related compounds, such as (\u00b1)\u2010norephedrine, (\u00b1)\u2010<jats:italic>N<\/jats:italic>\u2010methylephedrine, (\u00b1)\u2010ephedrine and (+)\u2010pseudoephedrine. The influence of some crucial parameters such as buffer concentration, pH value, DM\u2010<jats:italic>\u03b2<\/jats:italic>\u2010CD concentration, applied voltage and separation temperature on the separation was investigated. Under the optimum conditions, i.e. 40 mm DM\u2010<jats:italic>\u03b2<\/jats:italic>\u2010CD in 75 m<jats:sc>m<\/jats:sc> Tris (pH 2.5) as the running electrolyte, separation voltage +25 kV and temperature 25\u00b0C, a satisfactory separation of the enantiomers was accomplished. The detection limits (S\/N = 3) ranged from 65 to 161 ng\/mL and the linear range was 0.15 to 101.0 \u00b5g\/mL for pressure injection. The present method was successfully applied for the analysis of a series of drugs such as anti\u2010tussive, the drug for rheum, the drug for rhinitis and a Chinese traditional herbal medicine, <jats:italic>Ephedrae herba<\/jats:italic> (Ma\u2010Huang in Chinese). The recoveries of ephedrine and related compounds in real samples ranged from 97.6 to 103.5%. This method is useful in the simple and rapid analysis of ephedrine derivatives in marketed products. Copyright \u00a9 2005 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/bmc.504","type":"journal-article","created":{"date-parts":[[2005,7,21]],"date-time":"2005-07-21T12:07:19Z","timestamp":1121947639000},"page":"447-453","source":"Crossref","is-referenced-by-count":11,"title":["Application of dimethyl\u2010<i>\u03b2<\/i>\u2010cyclodextrin as a chiral selector in capillary electrophoresis for enantiomer separation of ephedrine and related compounds in some drugs"],"prefix":"10.1002","volume":"19","author":[{"given":"Li\u2010Bin","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Xia","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Ming","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,7,21]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"1","volume-title":"The Impact of Stereochemistry on Drug Development and Use","author":"Aboul\u2010Enein HY","year":"1997"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2683(200109)22:15<3107::AID-ELPS3107>3.0.CO;2-Z"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)00134-5"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(97)00752-8"},{"volume-title":"Capillary Electrophoresis in Chiral Analysis","year":"1997","author":"Chankvetadze B","key":"e_1_2_1_6_1"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-9936(99)00121-1"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1615-9314(20010901)24:9<691::AID-JSSC691>3.0.CO;2-E"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)01124-9"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac00036a021"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s0021663540451","article-title":"Separation and determination of some stereoisomers by capillary gel electrophoresis with cyclodextrin incorporated in polyacrylamide gel","volume":"354","author":"Lin JM","year":"1996","journal-title":"Fresenius Journal Analytical Chemistry"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9673(93)83218-H"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)00532-X"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-4347(00)82279-3"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2683(200109)22:15<3079::AID-ELPS3079>3.0.CO;2-F"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-200204000-00010"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbmc.504","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T23:56:38Z","timestamp":1760054198000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["10.1002\/bmc.504"],"URL":"https:\/\/doi.org\/10.1002\/bmc.504","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"type":"print","value":"0269-3879"},{"type":"electronic","value":"1099-0801"}],"subject":[],"published":{"date-parts":[[2005,7]]}}}