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In this study, a five\u2010step strategy based on ultra\u2010performance liquid chromatography coupled with quadrupole time\u2010of\u2010flight tandem mass spectrometry and metabolynx\u2122 software combined with mass defect filter technique was developed to delineate the metabolic profile of JHT <jats:italic>in vivo<\/jats:italic>. As a result, a total of 163 JHT\u2010related xenobiotics (38 prototypes and 125 metabolites) were identified or tentatively characterized in rat biological samples, and the phase I and II metabolism processes mainly included demethylation, hydroxylation, sulfation, and glucuronidation. In addition, after oral administration of JHT, a large amount of alkaloid\u2010related ingredients was detected in rat plasma samples, indicating that alkaloids may play an important role in the treatment of CSG with JHT. This study is beneficial for understanding the JHT\u2019s <jats:italic>in vivo<\/jats:italic> metabolic profiles and characteristics, which helps to reveal its <jats:italic>in vivo<\/jats:italic> effective components and provides a solid basis for further studies on its functional mechanism.<\/jats:p>","DOI":"10.1002\/bmc.5072","type":"journal-article","created":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T11:50:20Z","timestamp":1610797820000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Metabolic profiles of Jin\u2010hong tablets in rats by ultra\u2010performance liquid chromatography coupled with quadrupole time\u2010of\u2010flight tandem mass spectrometry"],"prefix":"10.1002","volume":"35","author":[{"given":"Ling\u2010Xian","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Traditional Chinese Medicine &amp; Natural Products, College of Pharmacy and Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research Jinan University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Cao","sequence":"additional","affiliation":[{"name":"Jiangsu Kanion Pharmaceutical Co. 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