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The prevalence of hypo\u2010HDL cholesterolemia is as high as 33.9%. The plasma metabolomic differences between hypo\u2010HDL cholesterolemia populations and normal controls were investigated using ultra\u2010high\u2010performance liquid chromatography\u2013quadrupole time\u2010of\u2010flight mass spectrometry. Participants with hypo\u2010HDL cholesterolemia and normal controls were clearly discriminated from each other on the orthogonal partial least squares\u2013discriminant analysis score plot and a total of 90 differential metabolites were identified, including down\u2010regulated phosphatidylserine [18:0\/20:3(8<jats:italic>Z<\/jats:italic>,11<jats:italic>Z<\/jats:italic>,14<jats:italic>Z<\/jats:italic>)], phosphatidylcholine [19:0\/18:3(6<jats:italic>Z<\/jats:italic>,9<jats:italic>Z<\/jats:italic>,12<jats:italic>Z<\/jats:italic>)], phosphatidylserine, phosphatidylethanolamine [18:0\/20:4(5<jats:italic>Z<\/jats:italic>,8<jats:italic>Z<\/jats:italic>,11<jats:italic>Z<\/jats:italic>,13<jats:italic>E<\/jats:italic>) (15Ke)], etc., and up\u2010regulated triglyceride [15:0\/18:1(9<jats:italic>Z<\/jats:italic>)\/18:3(9<jats:italic>Z<\/jats:italic>,12<jats:italic>Z<\/jats:italic>,15<jats:italic>Z<\/jats:italic>)][iso6], 13\u2010methyl\u20101\u2010tritriacontene, tridodecylamine, etc. Most of the changed metabolites were lipids, notably, a significant part of which were odd chain fatty acid incorporated lipids. Carnitine shuttle was the most significant metabolic pathway, except for the disturbed glycerophospholipid metabolism, glycosphingolipid metabolism and sphingolipid metabolism in participants with hypo\u2010HDL cholesterolemia. We identified the key metabolites and metabolic pathways that may be changed in hypo\u2010HDL cholesterolemia participants, providing useful clues for studying the metabolic mechanisms and for early prevention of hypo\u2010HDL cholesterolemia and dyslipidemia.<\/jats:p>","DOI":"10.1002\/bmc.5073","type":"journal-article","created":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T12:29:32Z","timestamp":1610800172000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolomic analysis of plasma from normal\u2010weight adults with hypo\u2010HDL cholesterolemia by UPLC\u2013QTOF MS"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3422-3806","authenticated-orcid":false,"given":"Pei","family":"Han","sequence":"first","affiliation":[{"name":"College of Public Health Zhengzhou University  Zhengzhou Henan 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