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A metabolomic approach based on an ultra\u2010high performance liquid chromatography\u2013Orbitrap analytical method was established to analyze the metabolites and to investigate the therapeutic mechanism of colchicine. Forty\u2010six biomarkers were significantly changed between the sham group and the MI group. Thirty\u2010five metabolites were increased and 11 were decreased in MI rats, and colchicine reversed all of them. Pathway analysis showed that the TCA cycle, alanine, aspartate and glutamate metabolism, glycerophospholipid metabolism, aminoacyl\u2010tRNA biosynthesis, glyoxylate and dicarboxylate metabolism and arginine biosynthesis were altered in the MI group. Ingenuity pathway function and network analysis showed that colchicine improved MI through regulation of cardiac <jats:italic>\u03b2<\/jats:italic>\u2010adrenergic signaling and cardiac hypertrophy signaling. The present study provided a useful approach for exploring the mechanism of MI and evaluating the efficacy of colchicine.<\/jats:p>","DOI":"10.1002\/bmc.5148","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T23:56:05Z","timestamp":1619567765000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Orbitrap\u2010MS\u2010based untargeted metabolomics study on the therapeutic effect of colchicine on myocardial infarction"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3929-4424","authenticated-orcid":false,"given":"Wei","family":"Wen","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, East Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongxiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hongqiao International Institute of Medicine Tongren Hospital, Shanghai Jiao Tong University School of Medicine  Shanghai People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3047-7590","authenticated-orcid":false,"given":"Bing","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, East Hospital Tongji University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2020.105466"},{"issue":"111","key":"e_1_2_8_3_1","first-page":"e54100","article-title":"Myocardial infarction in neonatal mice, a model of cardiac regeneration","author":"Blom J. 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