{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:31:23Z","timestamp":1786977083963,"version":"build-2736575974"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T00:00:00Z","timestamp":1621209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    A stability\u2010indicating HPLC method was developed for the simultaneous determination of paraben mixture and its degradation products in effervescent potassium chloride tablets. The chromatographic separation was achieved on a Waters Cortecs C18 column (2.7\u2009\u03bcm, 4.6\u2009\u00d7\u2009150\u2009mm) using gradient elution. The optimized mobile phase consisted of 0.1% orthophosphoric acid in purified water as solvent A and purified water, acetonitrile, and orthophosphoric acid (100:900:1, v\/v) as solvent B. The flow rate was 0.8\u2009mL\/min, and column temperature was maintained at 35\u00b0C. The injection volume was 10\u2009\u03bcL, and UV detection was carried out at 254\u2009nm. The selectively developed method has optimal separation among\n                    <jats:italic>p<\/jats:italic>\n                    \u2010hydroxybenzoic acid, methylparaben, ethylparaben, propylparaben, and butylparaben peaks in the presence of specified and unspecified degradation products in the determination of drug product. The mass balance obtained from forced degradation studies was \u226595% and thus proves the stability\u2010indicating property of the developed method. The developed reversed\u2010phase HPLC method has been validated according to the International Conference on Harmonization guidelines. The correlation coefficients for all the peaks were &gt;0.9999. The results of the other validation parameters were found within the limits. Finally, the optimized method was used in the quality control lab for stability analysis.\n                  <\/jats:p>","DOI":"10.1002\/bmc.5152","type":"journal-article","created":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:34:31Z","timestamp":1619829271000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["A simple and rapid HPLC method for determination of parabens and their degradation products in pharmaceutical dosage forms"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9036-2205","authenticated-orcid":false,"given":"Lakshmi Narasimha Rao","family":"Katakam","sequence":"first","affiliation":[{"name":"Department of Chemistry JNTU Hyderabad  Hyderabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santhosh Kumar","family":"Ettaboina","sequence":"additional","affiliation":[{"name":"Quality Control Aurex Laboratories LLC  East Windsor New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thirupathi","family":"Dongala","sequence":"additional","affiliation":[{"name":"Quality Control Aurex Laboratories LLC  East Windsor New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2005.12.026"},{"issue":"6","key":"e_1_2_7_3_1","first-page":"p3449","article-title":"Simultaneous determination of preservatives benzyl alcohol, methyl paraben and propyl paraben used in Imiquimod cream using RP\u2010HPLC\u2010PDA","volume":"5","author":"Bachute M. T.","year":"2012","journal-title":"Journal of Pharmacy Research"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/22297928.2019.1696701"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4909547"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0731-7085(03)00193-6"},{"key":"e_1_2_7_7_1","unstructured":"International Conference on Harmonization. (2000).Stability testing of new drug substances and products. Geneva. ICH Q1A (R2)"},{"key":"e_1_2_7_8_1","unstructured":"International Conference on Harmonization. (2005).Validation of Analytical Procedures Text and Methodology. 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