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It has been reported that consuming <jats:italic>V. articulatum<\/jats:italic> can prevent cardiac diseases. In this study, six bioactive compounds, including catechins, triterpenoids, and phenylpropanoid glycosides, were determined in alcohol extracts of the plant using HPLC. The anti\u2010inflammatory and antioxidant activities of three catechins, two triterpenoids, and three combination drugs were measured in cardiomyocytes, and the results showed that the anti\u2010inflammatory activity was significantly enhanced while retaining strong antioxidant activity when epicatechin and ursolic acid were used in combination. The main quality markers epicatechin and ursolic acid were screened based on the specificity of the genuine herb and a potent synergistic effect, and the lowest limitation contents of <jats:italic>V. articulatum<\/jats:italic> which could discriminate it from some other taxonomically similar materials were accordingly determined. This self\u2010built lowest limitation content of the two screened quality markers could quickly and accurately reflect the efficacy in terms of chemical composition and reverse the disorderly market use of nongenuine herbs or confusing species for adulteration. This study is of some significance for market regulation, drug development, and clinical medication.<\/jats:p>","DOI":"10.1002\/bmc.5175","type":"journal-article","created":{"date-parts":[[2021,8,13]],"date-time":"2021-08-13T21:28:27Z","timestamp":1628890107000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Chemical\u2010activity\u2010based quality marker screening strategy for <i>Viscum articulatum<\/i>"],"prefix":"10.1002","volume":"35","author":[{"given":"Xu\u2010Ya","family":"Wei","sequence":"first","affiliation":[{"name":"Academician Workstation Jiangxi University of Traditional Chinese Medicine  Nanchang China"},{"name":"State Key Laboratory of Dao\u2010di Herbs, National Resource Center for Chinese Materia Medica China Academy of Chinese Medical Sciences  Beijing 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