{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T14:00:26Z","timestamp":1787320826996,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,7,31]],"date-time":"2021-07-31T00:00:00Z","timestamp":1627689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The stems of\n                    <jats:italic>Nauclea officinalis<\/jats:italic>\n                    have been utilized as a crude drug in China, so other parts of the plant are abandoned, resulting in a waste of traditional Chinese medicine resources. To determine the distribution and content of the alkaloids, phenolic acids and iridoid in different organs (stem, branch, leaf and bark) of this plant, a reliable method has been established using LC\u2013MS\/MS. Nine constituents, namely strictosamide, vincosamide, chlorogenic acid, sweroside, naucleamide B, protocatechuic acid, pumiloside, vanillic acid and cryptochlorogenic acid, were simultaneously determined in 6 min. Meanwhile, the antipyretic, anti\u2010inflammatory and analgesic activities were evaluated for comparative analysis of the pharmacological activity of different parts of\n                    <jats:italic>N. officinalis<\/jats:italic>\n                    . The results showed that the content of active components in other organs of\n                    <jats:italic>N. officinalis<\/jats:italic>\n                    was higher than that in stems, and the pharmacological effects of branches and leaves were also better. The established approach could be helpful for the quality control of\n                    <jats:italic>N. officinalis<\/jats:italic>\n                    , and also provide necessary information for the rational utilization of resources.\n                  <\/jats:p>","DOI":"10.1002\/bmc.5214","type":"journal-article","created":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T14:46:30Z","timestamp":1626101190000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Comparative analysis of bioactive constituents and pharmacological activities from different parts of\n                    <i>Nauclea officinalis<\/i>"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9210-4151","authenticated-orcid":false,"given":"Mingyan","family":"Zhou","sequence":"first","affiliation":[{"name":"Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, School of Pharmacy Hainan Medical University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenrui","family":"Xie","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, School of Pharmacy Hainan Medical University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Guan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, School of Pharmacy Hainan Medical University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, School of Pharmacy Hainan Medical University  Haikou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1977.tb11330.x"},{"key":"e_1_2_8_3_1","first-page":"434","article-title":"Simultaneous determination of six main compounds in Nauclea officinalis by ultraperformance liquid chromatography","volume":"45","author":"Chen J.\u2010Q.","year":"2014","journal-title":"Journal of China Pharmaceutical University"},{"key":"e_1_2_8_4_1","first-page":"456","volume-title":"Chinese herbs","author":"Editorial Committee of Chinese Herbs","year":"1999"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21080968"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-013-0674-4"},{"key":"e_1_2_8_7_1","first-page":"79","article-title":"Inhibitory effect of Nauclea officinalis Pierre ex Pitard. Extract and different antibiotic combinations on Staphylococcus aureus","volume":"46","author":"Jiang P.","year":"2018","journal-title":"Guizhou Agricultural Sciences"},{"key":"e_1_2_8_8_1","first-page":"412","article-title":"Acetic acid for analgesic screening","volume":"18","author":"Koster R.","year":"1959","journal-title":"Federation Proceedings"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2008.07.006"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.12.007"},{"key":"e_1_2_8_11_1","first-page":"104","article-title":"Isolation, identification and quality control of strictosamide from Nauclea officinalis and its preparations","volume":"4","author":"Li M.\u2010H.","year":"2006","journal-title":"Chinese Journal of Natural Medicines"},{"key":"e_1_2_8_12_1","first-page":"50","article-title":"Advances in study on phenolic acids","volume":"44","author":"Lin P.\u2010F.","year":"2014","journal-title":"Guangdong Chemical Industry"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2016.1277351"},{"key":"e_1_2_8_14_1","first-page":"52","article-title":"Chemical constituents from stems and leaves of Nauclea officinalis","volume":"48","author":"Liu Q.\u2010L.","year":"2017","journal-title":"Chinese Traditional and Herbal Drugs"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.10.013"},{"key":"e_1_2_8_16_1","first-page":"167","article-title":"Chemical constituents from Nauclea officinalis","volume":"13","author":"Ma W.\u2010Z.","year":"2015","journal-title":"Journal of Tropical and Subtropical Botany"},{"key":"e_1_2_8_17_1","first-page":"38","article-title":"Research Progress on chemical constituents and pharmacological activity of Nauclea officinalis","volume":"46","author":"Mai S.\u2010Y.","year":"2018","journal-title":"Guangzhou Chemical Industry"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1076\/phbi.35.2.99.13288"},{"key":"e_1_2_8_19_1","first-page":"1","article-title":"A new indole alkaloid with anti\u2010inflammatory from the branches of Nauclea officinalis","volume":"22","author":"Song L.\u2010L.","year":"2018","journal-title":"Natural Product Research"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2019.1700248"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.04.018"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2012.04.024"},{"key":"e_1_2_8_23_1","first-page":"2326","article-title":"Simultaneous determination of phenolic acid and three alkaloids in Nauclea officinalis and its preparations by HPLC","volume":"34","author":"Wang J.\u2010J.","year":"2012","journal-title":"Chinese Traditional Patent Medicine"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24050872"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2018.04.046"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.01.018"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2016.01.018"},{"key":"e_1_2_8_28_1","first-page":"173","article-title":"Studies on bioactivities of chlorogenic acid and its analogues","volume":"32","author":"Zhang A.\u2010L.","year":"2001","journal-title":"Chinese Traditional and Herbal Drugs"},{"key":"e_1_2_8_29_1","first-page":"1654","article-title":"The qualitative research of the isovincoside lactone in different parts of Nauclea officinalis Pierrc ex Pitard","volume":"28","author":"Zhang J.\u2010Q.","year":"2008","journal-title":"Chinese Journal of Pharmaceutical Analysis"},{"key":"e_1_2_8_30_1","first-page":"2097","article-title":"Study on quality standard for the leaves of Nauclea officinalis","volume":"28","author":"Zhang X.\u2010Q.","year":"2017","journal-title":"China Pharmacy"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.5214","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bmc.5214","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.5214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:13:46Z","timestamp":1760044426000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.5214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,31]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1002\/bmc.5214"],"URL":"https:\/\/doi.org\/10.1002\/bmc.5214","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"value":"0269-3879","type":"print"},{"value":"1099-0801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,31]]},"assertion":[{"value":"2021-03-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e5214"}}