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The clinical importance of sofosbuvir is based not only on its effect on HCV but also on other lethal viruses such as Zika and severe acute respiratory syndrome coronavirus disease 2019 (SARS\u2010COVID\u201019). Accordingly, there is a continuous shedding of light on the development and validation of accurate and fast analytical methods for the determination of sofosbuvir in different environments. This work critically reviews the recent advances in chromatographic methods for the analysis of sofosbuvir and\/or its metabolites in pure samples, pharmaceutical dosage forms, and in the presence of other co\u2010administered drugs to highlight the current status and future perspectives to enhance its determination in different matrixes.<\/jats:p>","DOI":"10.1002\/bmc.5238","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T13:29:54Z","timestamp":1630502994000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Recent advances in the chromatographic determination of the most commonly used anti\u2010hepatitis C drug sofosbuvir and its co\u2010administered drugs in human plasma"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3874-6652","authenticated-orcid":false,"given":"Muhammed Abdel\u2010Hamied","family":"Abdel\u2010Tawab","sequence":"first","affiliation":[{"name":"Chemistry Department, Faculty of Science Cairo University  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad G.","family":"Abd El\u2010Moghny","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Science Cairo University  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6150-8420","authenticated-orcid":false,"given":"Rasha Mohamed","family":"El Nashar","sequence":"additional","affiliation":[{"name":"Chemistry Department, Faculty of Science Cairo University  Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,27]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"1","article-title":"Selective and sensitive electrochemical sensor based on molecular imprinting strategy for recognition and quantification of sofosbuvir in real samples","author":"Abdallah A. 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