{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:32:20Z","timestamp":1761611540840,"version":"build-2065373602"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T00:00:00Z","timestamp":1634083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373942"],"award-info":[{"award-number":["81373942"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Osmundacetone is a potential medicinal substance existing in ferns and has excellent antioxidant effects. This research aims to obtain the pharmacokinetic data for and metabolite products of osmundacetone. An UPLC\u2013MS\/MS quantitative method was established for the measurement of osmundacetonein in rat plasma over a linear range of 6.72\u2013860.00\u00a0ng\/ml. The signal to noise ratio of the lower limit of quantification was 60:1, the precision was &lt;9.74% and the method had good selectivity and stability. The established method was successfully applied to the pharmacokinetic study of osmundacetone for the first time. Osmundacetone reached a peak at 0.25\u2009h with a maximum value of 3283.33\u2009\u03bcg\/L. The apparent volume of distribution not multiplied by the bioavailability was 127.96\u2009L\/kg, and the half\u2010life of osmundacetone was 5.20\u2009h. At the same time, an UPLC\u2013QE\u2013Orbitrap\u2013HRMS method was established to identify metabolites in plasma, urine and feces for the first time. A total of 30 metabolites were identified and the metabolic profile of osmundacetone was defined. In general, we have established a mass spectrometry quantitative method for osmundacetone for the first time and characterized its metabolic characteristics in rats.<\/jats:p>","DOI":"10.1002\/bmc.5251","type":"journal-article","created":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T16:06:21Z","timestamp":1633449981000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pharmacokinetic and metabolic profiling studies of osmundacetone in rats by UPLC\u2013MS\/MS and UPLC\u2013QE\u2013Orbitrap\u2013HRMS"],"prefix":"10.1002","volume":"36","author":[{"given":"Hao","family":"Wu","sequence":"first","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yijia","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runhua","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3649-2428","authenticated-orcid":false,"given":"Chenning","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing China"},{"name":"Department of Clinic Medical Center, Department of Pharmacy Dazhou Central Hospital  Dazhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5943-5119","authenticated-orcid":false,"given":"Yikun","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Chinese Materia Medica Beijing University of Chinese Medicine  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,13]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26061657"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2018.1501692"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.06.014"},{"key":"e_1_2_9_5_1","unstructured":"Flora of China Editorial Committee of Chinese Academy of Sciences(1900).Flora of China Volume Two: Flora of China (Vol. Two)."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9030597"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21072453"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2019.112997"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26080"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11020328"},{"key":"e_1_2_9_11_1","unstructured":"US Department of Health and Human Services. 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