{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T04:48:02Z","timestamp":1792212482540,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T00:00:00Z","timestamp":1639526400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\"><jats:italic>Periplaneta americana<\/jats:italic><\/jats:styled-content> (PA) is used as a traditional medicine for hepatic diseases such as hepatic fibrosis in China. However, the relationship between the corresponding therapeutic effect and the chemical composition is still unclear. In this study, spectrum\u2013effect relationship and chemical component separation were used to discover the potential of anti\u2013hepatic fibrosis components of PA. The fingerprints of 10 batches of samples were established using HPLC, and the anti\u2013hepatic fibrosis effect was determined using HSC\u2010T6 cells. The spectrum\u2013effect relationship between common peaks and efficacy values was established using partial least squares analysis. Partial peaks in the fingerprints were identified, including X<jats:sub>4<\/jats:sub> (9,12\u2010heptadecanedenoic acid glyceride), X<jats:sub>5<\/jats:sub> (nonadecanoic acid methyl ester), X<jats:sub>6<\/jats:sub> (glyceryl oleate), X<jats:sub>7<\/jats:sub> (13,16,19\u2010eicosatrienoic acid), X<jats:sub>9<\/jats:sub> (linoleic acid), X<jats:sub>10<\/jats:sub> (9,12,15\u2010octadecatrienoic acid glyceride), X<jats:sub>12<\/jats:sub> (hexadecanoic acid), X<jats:sub>13<\/jats:sub> (oleic acid), and X<jats:sub>14<\/jats:sub> (octadecanoic acid), and their anti\u2013hepatic fibrosis activity was tested to verify the results of spectrum\u2013effect relationships. The results showed that X<jats:sub>4<\/jats:sub>, X<jats:sub>6<\/jats:sub>, X<jats:sub>7<\/jats:sub>, and X<jats:sub>10<\/jats:sub> were the active ingredients of PA. This work successfully identified the partial anti\u2013hepatic fibrosis components of PA, which can be used to explain the material basis for the PA anti\u2013hepatic fibrosis effect.<\/jats:p>","DOI":"10.1002\/bmc.5286","type":"journal-article","created":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T01:30:41Z","timestamp":1637976641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Identification of anti\u2013hepatic fibrosis components in <scp><i>Periplaneta americana<\/i><\/scp> based on spectrum\u2013effect relationship and chemical component separation"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6629-2320","authenticated-orcid":false,"given":"Wenpeng","family":"Fu","sequence":"first","affiliation":[{"name":"Anti\u2010fibrosis Research Team of Natural Products, College of Pharmacy Dali University  Dali Yunnan China"},{"name":"Qujing Xuanwei City First Occupation Technical School  Xuanwei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanwen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Anti\u2010fibrosis Research Team of Natural Products, College of Pharmacy Dali University  Dali Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Xie","sequence":"additional","affiliation":[{"name":"Anti\u2010fibrosis Research Team of Natural Products, College of Pharmacy Dali University  Dali Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongshou","family":"Yang","sequence":"additional","affiliation":[{"name":"Anti\u2010fibrosis Research Team of Natural Products, College of Pharmacy Dali University  Dali Yunnan China"},{"name":"Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&amp;D  Dali Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiyun","family":"Xiao","sequence":"additional","affiliation":[{"name":"Anti\u2010fibrosis Research Team of Natural Products, College of Pharmacy Dali University  Dali Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,15]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"116","article-title":"Herbal textual research on cockroach","volume":"39","author":"Bai Y. 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