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Exposure to BTEX poses a health hazard by increasing the risk for damage to multiple organs, neurocognitive impairment and birth defects. Urinary BTEX metabolites are useful biomarkers for the evaluation of BTEX exposure, because of the ease of sampling and their longer physiological half\u2010lives compared with parent compounds. A method that utilizes LC\u2013MS\/MS was developed and validated for simultaneously monitoring of 10 urinary BTEX metabolites. During the sample preparation an aliquot of urine was diluted with an equal volume of 1% formic acid; internal standard solution was added, and then the sample was centrifuged and analyzed. The analytes were separated on the Kinetex\u2010F5 column by applying a linear gradient, consisting of 0.1% formic acid and methanol. The method was validated according to the FDA Bioanalytical Method Validation Guidance for Industry. The mean method's accuracies of the spiked matrix were 81\u2013122%; the inter\u2010day precision ranged from 4 to 20%; the limits of quantitation were 0.5\u20132\u00a0\u03bcg\/L. The method was used for the evaluation of baseline levels of urinary BTEX metabolites in 87 firefighters.<\/jats:p>","DOI":"10.1002\/bmc.5302","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T01:38:46Z","timestamp":1640137126000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Analysis of 10 urinary BTEX metabolites using LC\u2013MS\/MS"],"prefix":"10.1002","volume":"36","author":[{"given":"Elkana","family":"Kohn","sequence":"first","affiliation":[{"name":"Clinical Pharmacology and Toxicology Unit Shamir Medical Center  Zerifin Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Barchel","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology and Toxicology Unit Shamir Medical Center  Zerifin Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahuva","family":"Golik","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology and Toxicology Unit Shamir Medical Center  Zerifin Israel"},{"name":"Adelson School of Medicine Ariel University  Ariel Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Lougassi","sequence":"additional","affiliation":[{"name":"Negev Nuclear Research Center  Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamar","family":"Wainstock","sequence":"additional","affiliation":[{"name":"Department of Public Health, Faculty of Health Sciences Ben\u2010Gurion University of the Negev  Beer Sheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matitiahu","family":"Berkovitch","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology and Toxicology Unit Shamir Medical Center  Zerifin Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7413-9799","authenticated-orcid":false,"given":"Frieda","family":"Schwartsburd","sequence":"additional","affiliation":[{"name":"National Residue Control Laboratory Kimron Veterinary Institute, Veterinary Services, Ministry of Agriculture and Rural Development  Beit Dagan Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,3]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"Agency for Toxic Substances and Disease Registry (ATSDR). 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