{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T10:45:56Z","timestamp":1771065956949,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:00:00Z","timestamp":1645056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cyclizine hydrochloride (CYC) and meclozine hydrochloride (MEC) are antihistaminic drugs generally co\u2010formulated with pyridoxine hydrochloride (PYR) to treat nausea and vomiting in pregnancy. Several analytical techniques have been applied for the determination of CYC or MEC with PYR, but determination of CYC impurity; benzhydrol (BEH) or MEC impurity; or 4\u2010chlorobenzophenone (BEP) has not been paid attention to. Therefore, micellar UPLC method is introduced for analysis of ternary mixtures containing PYR together with both CYC and BEH (mixture I) or MEC and BEP (mixture II). Chromatographic separation was achieved using a Hypersil gold C<jats:sub>8<\/jats:sub> column (50\u2009\u00d7\u20092.1\u00a0mm, 1.9\u00a0\u03bcm) using 0.01\u2009M sodium dodecyl sulfate modified to pH\u00a03.5 using phosphoric acid:acetonitrile (45:55 by volume) for mixture I and 0.1% sodium dodecyl sulfate, 0.1% sodium bicarbonate adjusted to pH\u00a02.6 by phosphoric acid:acetonitrile (47:53 by volume) for mixture II as mobile phases. The separated peaks were detected at 230 and 245\u2009nm for mixtures I and II, respectively. The adopted methods were validated in conformance with the International Conference on Harmonization (ICH) recommendations and were properly applied in commercial pharmaceutical formulation analysis. Comprehensive ecological comparison was achieved, confirming a higher ecological value of the presented methods compared to the earlier reported methods.<\/jats:p>","DOI":"10.1002\/bmc.5353","type":"journal-article","created":{"date-parts":[[2022,2,6]],"date-time":"2022-02-06T20:59:46Z","timestamp":1644181186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impurity\u2010profiling UPLC methods for quantitative analysis of some antiemetics formulated with pyridoxine"],"prefix":"10.1002","volume":"36","author":[{"given":"Ahmed S.","family":"Saad","sequence":"first","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy Cairo University  Cairo Egypt"},{"name":"Medicinal Chemistry Department (Pharm D Program), Basic and Applied Sciences Institute Egypt\u2010Japan University of Science and Technology (E\u2010JUST)  Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed E.","family":"Draz","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Delta University for Science &amp; Technology  Mansoura Dakahlia Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim A.","family":"Naguib","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, College of Pharmacy Taif University  Taif Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hala E.","family":"Zaazaa","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy Cairo University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adel S.","family":"Lashien","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Department, Faculty of Pharmacy Nahda University  Beni Suef Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1374-7907","authenticated-orcid":false,"given":"Fatma F.","family":"Abdallah","sequence":"additional","affiliation":[{"name":"Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy Beni\u2010Suef University  Beni Suef Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,2,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1211\/146080899128735199"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1365\/s10337-008-0615-5"},{"issue":"2","key":"e_1_2_10_4_1","first-page":"149","article-title":"Spectrophotometric methods for the simultaneous analysis of meclezine hydrochloride and pyridoxine hydrochloride in bulk drug and pharmaceutical formulations","volume":"20","author":"Arayne M. 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