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A simple protein precipitation was performed for the extraction of analytes and the extracted samples were injected directly. The levels of drugs and their metabolites were measured by the validated method in a total of 210 patients diagnosed with unstable angina pectoris (USAP), ST\u2010elevation myocardial infarction (STEMI) or non\u2010ST\u2010elevation myocardial infarction (NSTEMI). Various biochemical and hematological parameters were measured. The linearity ranges for atorvastatin and rosuvastatin were 1.22\u20132,500\u2009and 0.97\u20132000\u2009ng\/ml, respectively. The inter\u2010assay coefficient of variation for all analytes was \u2264 6%. In patients diagnosed with USAP, STEMI and NSTEMI, treatment compliance rates were 22.1, 23.5 and 41.2% for atorvastatin and 36.1, 40.2 and 67.1% for rosuvastatin, respectively. An economical, simple and reliable measurement method has been developed. Our findings support the poor patient compliance with statin therapy in the included population. It was observed that 6\u00a0months of statin treatment caused slight changes in biochemical and hematological parameters.<\/jats:p>","DOI":"10.1002\/bmc.5390","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T20:49:27Z","timestamp":1651265367000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["New steps in acute coronary syndrome and antihyperlipidemic treatment: Determination of statins and metabolites by liquid chromatography tandem mass spectrometry"],"prefix":"10.1002","volume":"36","author":[{"given":"Havva","family":"Yaglioglu","sequence":"first","affiliation":[{"name":"Department of Biochemistry Selcuk University Faculty of Medicine  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8564-1824","authenticated-orcid":false,"given":"Duygu","family":"Eryavuz Onmaz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Selcuk University Faculty of Medicine  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2984-0527","authenticated-orcid":false,"given":"Sedat","family":"Abusoglu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Selcuk University Faculty of Medicine  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenan","family":"Erdem","sequence":"additional","affiliation":[{"name":"Department of Cardiology Selcuk University Faculty of Medicine  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah","family":"Sivrikaya","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Selcuk University Faculty of Medicine  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gulsum","family":"Abusoglu","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Techniques Selcuk University Vocational School of Health  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Unlu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Selcuk University Faculty of Medicine  Konya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008226.pub3"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.09.017"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2016.09.075"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/dhps.s4928"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2006.12.030"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e3181c132ad"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.487017"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1556\/1326.2016.28.3.1"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/chromsci\/bmt109"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2019.05.069"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2018.10.045"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/omcr\/omx104"},{"key":"e_1_2_9_14_1","unstructured":"FDA(2018).Guidance for Industry Bionanalytical Method Validation. 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