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First, the fingerprint of 16 batches of YZP was studied using the ultra\u2010high\u2010performance liquid chromatography\u2010quadrupole mass spectrometry detector analysis (UPLC\u2010QDA) method. Second, gastric lesion was induced by anhydrous ethanol. The degree of gastric mucosa injury was evaluated by hematoxylin and eosin staining, and the contents of malondialdehyde and tumor necrosis factor \u03b1 and superoxide dismutase were detected using the enzyme\u2010linked immunosorbent assay kit. Sixteen batches of YZP were analyzed using the spectrum\u2010effect relationship method. Finally, absorption, distribution, metabolism, and excretion (ADME) was used to evaluate the bioavailability of potential compounds. The results showed that the UPLC\u2010QDA method could successfully establish the fingerprint of YZP. Hematoxylin and eosin staining and biochemical indicators showed that YZP had obvious anti\u2010alcoholic gastric ulcer action. Coptisine chloride, corydaline, berberine chloride, palmatine, imperatorin, and phellopterin were screened out using the spectrum\u2010effect method, and all of them possessed good bioavailability. The results of this study suggest that YZP plays an anti\u2010ulcer role by exerting antioxidant and anti\u2010inflammatory effects through six main active components.<\/jats:p>","DOI":"10.1002\/bmc.5410","type":"journal-article","created":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T21:11:15Z","timestamp":1652735475000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["The effect of anti\u2010alcoholic gastric ulcer before and after vinegar\u2010processed Yuanhu Zhitong prescription based on spectral\u2010effect relationship"],"prefix":"10.1002","volume":"36","author":[{"given":"Xuejiao","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao Heilongjiang University of Chinese Medicine, Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao Heilongjiang University of Chinese Medicine, Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajiao","family":"Hou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao Heilongjiang University of Chinese Medicine, Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao Heilongjiang University of Chinese Medicine, Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao Heilongjiang University of Chinese Medicine, Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senwang","family":"Zheng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao Heilongjiang University of Chinese Medicine, Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao Heilongjiang University of Chinese Medicine, Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Lv","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao Heilongjiang University of Chinese Medicine, Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaojiao","family":"Dong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao Heilongjiang University of Chinese Medicine, Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9607-1107","authenticated-orcid":false,"given":"Liu","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao Heilongjiang University of Chinese Medicine, Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixue","family":"Kuang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao Heilongjiang University of Chinese Medicine, Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2722-3330","authenticated-orcid":false,"given":"Hai","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Basic and Application Research of Beiyao Heilongjiang University of Chinese Medicine, Ministry of Education  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.19852\/j.cnki.jtcm.20210209.006"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106612"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO00645B"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-021-00868-x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00040.2012"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jssc.201100211"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)11030-0"},{"key":"e_1_2_11_9_1","volume-title":"Pharmacopoeia of People's Republic of China. 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