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Therefore, to promote the clinical application of docetaxel alone or in combination, a comprehensive investigation of the metabolic mechanism of docetaxel is of great importance. Here, we apply an integrative analysis of metabolomics and network pharmacology to elucidate the underlying mechanisms of docetaxel. After taking the intersection of the aforesaid two methods, five pathways including ABC (ATP\u2010binding cassette) transporters, central carbon metabolism in cancer, glycolysis and gluconeogenesis, cysteine and methionine metabolism, and arginine biosynthesis have been screened. Concerning the interaction network of these pathways and the anti\u2010apoptosis effect of docetaxel itself, the central carbon metabolism in cancer pathway was mainly focused on. This study may help delineate global landscapes of cellular protein\u2013metabolite interactions, to provide molecular insights about their mechanisms of action as well as to promote their clinical applications.<\/jats:p>","DOI":"10.1002\/bmc.5417","type":"journal-article","created":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T03:48:47Z","timestamp":1653709727000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Investigation of the apoptosis\u2010inducing effect of docetaxel by comprehensive LC\u2013MS\u2013based metabolomics and network pharmacology approaches"],"prefix":"10.1002","volume":"36","author":[{"given":"Dongyao","family":"Wang","sequence":"first","affiliation":[{"name":"School of Pharmacy, Shanghai Key Laboratory for Pharmaceutical Metabolite Research Second Military Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxiao","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Nutrition Second Military Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shanghai Key Laboratory for Pharmaceutical Metabolite Research Second Military Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minyu","family":"Qi","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shanghai Key Laboratory for Pharmaceutical Metabolite Research Second Military Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahao","family":"Fang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shanghai Key Laboratory for Pharmaceutical Metabolite Research Second Military Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shanghai Key Laboratory for Pharmaceutical Metabolite Research Second Military Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifeng","family":"Chai","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shanghai Key Laboratory for Pharmaceutical Metabolite Research Second Military Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Cao","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shanghai Key Laboratory for Pharmaceutical Metabolite Research Second Military Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6159-4311","authenticated-orcid":false,"given":"Diya","family":"Lv","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Shanghai Key Laboratory for Pharmaceutical Metabolite Research Second Military Medical University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119984"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1023\/b:brea.0000004374.72658.17"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-009-0430-1"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2017.5560"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.10.010"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.1995.13.10.2643"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13205059"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14081929"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199651060-00011"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.9-suppl_2-3"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/dote.12433"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ecc.12261"},{"issue":"10","key":"e_1_2_8_14_1","first-page":"5155","article-title":"Chemoresistance in breast cancer: PI3K\/Akt pathway inhibitors vs the current chemotherapy","volume":"11","author":"Kaboli P. 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