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The significance of operational factors on carbamazepine and furosemide extraction efficiency % (EE%) was screened using full factorial design (FFD) while central composite design (CCD) was used to model the entire process. A quadratic model was found convenient to correlate the extraction EE% of selected drugs with dominant experimental factors. A Pareto chart was also used to examine the importance of factors on drugs\u2019 EE%. The analytical performance of the method in urine and plasma samples demonstrated good linearity (R<jats:sup>2<\/jats:sup> \u02c3 0.992) with detection limits ranging from 4.2 to 10.9\u2009\u03bcg\u2009L<jats:sup>\u22121<\/jats:sup>, and extraction recovery over 89.45% for both drugs in urine and plasma samples. A comparison against published methods was also performed and the results revealed that the developed method exhibits a confident sensitivity, feasible operation, and simple analysis for both drugs. Finally, the practicability of the validated SBME\u2013HPLC\u2013DAD method was demonstrated by successfully applying it to the analysis of furosemide and carbamazepine in real patient urine samples.<\/jats:p>","DOI":"10.1002\/bmc.5476","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:59:40Z","timestamp":1659488380000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Simultaneous determination of furosemide and carbamazepine in biological matrices by solvent bar microextraction combined with high\u2010performance liquid chromatography\u2013diode array detector and central composite design"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1923-2405","authenticated-orcid":false,"given":"Nabil N.","family":"AL\u2010Hashimi","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences The 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