{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:47:40Z","timestamp":1762508860198,"version":"build-2065373602"},"reference-count":19,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,4]],"date-time":"2022-09-04T00:00:00Z","timestamp":1662249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073988","81703697"],"award-info":[{"award-number":["82073988","81703697"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Huangqi Jianzhong Tang (HQJZ) is a famous traditional Chinese medicine formula widely used in the treatment of gastrointestinal diseases in China. In this study, an ultra\u2010performance liquid chromatography\u2013mass spectrometry (UHPLC\u2013MS\/MS) was used to study the pharmacokinetics of 12 prototypical components and one metabolite in HQJZ in normal and chronic atrophic gastritis rats. The results showed that the area under the concentration\u2013time curve and peak concentration of most flavonoids and flavonoid glycosides were decreased, and the half\u2010life and mean residence time were significantly increased, which indicated that the absorption of drugs in disease was decreased less and for longer <jats:italic>in vivo<\/jats:italic>. Then, an integrated pharmacokinetic study was carried out using the pharmacokinetic parameter model integration of each component. The results showed that the absorption of drugs <jats:italic>in vivo<\/jats:italic> with disease was reduced, and the absorption speed of flavonoids and flavonoid glycosides was accelerated. This study will provide the basis for the clinical medication safety of HQJZ.<\/jats:p>","DOI":"10.1002\/bmc.5492","type":"journal-article","created":{"date-parts":[[2022,8,26]],"date-time":"2022-08-26T17:23:23Z","timestamp":1661534603000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Integrated pharmacokinetics of Huangqi Jianzhong Tang in normal and chronic atrophic gastritis rats"],"prefix":"10.1002","volume":"36","author":[{"given":"Lu","family":"Jia","sequence":"first","affiliation":[{"name":"Modern Research Center for Traditional Chinese Medicine, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Shanxi University  Taiyuan Shanxi P. R. China"},{"name":"Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province  Taiyuan Shanxi P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0020-3364","authenticated-orcid":false,"given":"Xuemei","family":"Qin","sequence":"additional","affiliation":[{"name":"Modern Research Center for Traditional Chinese Medicine, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Shanxi University  Taiyuan Shanxi P. R. China"},{"name":"Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province  Taiyuan Shanxi P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9829-0605","authenticated-orcid":false,"given":"Yuetao","family":"Liu","sequence":"additional","affiliation":[{"name":"Modern Research Center for Traditional Chinese Medicine, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Shanxi University  Taiyuan Shanxi P. R. China"},{"name":"Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province  Taiyuan Shanxi P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,4]]},"reference":[{"issue":"8","key":"e_1_2_10_2_1","first-page":"883","article-title":"The clinical effect research of modified Huangqi Jianzhong decoction combined with quadruple therapy in the treatment of type 2 diabetes mellitus with peptic ulcer and its effect on serum pepsinogen (PG)","volume":"29","author":"Bai N.","year":"2020","journal-title":"Chinese Journal of Convalescent Medicine"},{"issue":"8","key":"e_1_2_10_3_1","first-page":"757","article-title":"Reducing fatigue of athletes following oral administration of huangqi jianzhong tang","volume":"23","author":"Chen K. 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