{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T19:37:05Z","timestamp":1778009825295,"version":"3.51.4"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,17]],"date-time":"2023-01-17T00:00:00Z","timestamp":1673913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["Y21H280036"],"award-info":[{"award-number":["Y21H280036"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this study, we used a serum metabolomics methodology based on GC coupled with MS (GC\u2013MS) to investigate the liver\u2010protective effects of raw and stir\u2010fried semen of <jats:styled-content style=\"fixed-case\"><jats:italic>Hovenia dulcis<\/jats:italic><\/jats:styled-content> in rats models of carbon tetrachloride\u2013induced liver injury. Multivariate statistical analysis, such as principal component analysis and orthogonal partial least squares discriminant analysis, were performed to examine changes in the metabolic state of rats with carbon tetrachloride\u2013induced liver injury, as well as the recovery pattern of rats pretreated with the raw and stir\u2010fried semen of <jats:styled-content style=\"fixed-case\"><jats:italic>H. dulcis<\/jats:italic><\/jats:styled-content>. Liver tissues were subjected to histopathological examination. A total of 47 biomarkers were predicted to contribute to the dynamic pathological processes in the liver injury, such as phenylalanine, glutamic acid, glycine, arachidonic acid and linoleic acid. Further analysis revealed that pathways associated with phenylalanine, tyrosine and tryptophan biosynthesis, and linoleic acid metabolism were altered in the injured liver, and that pretreatment with raw and stir\u2010fried semen of <jats:styled-content style=\"fixed-case\"><jats:italic>H. dulcis<\/jats:italic><\/jats:styled-content> abolished the changes in the aforementioned metabolic pathways.<\/jats:p>","DOI":"10.1002\/bmc.5578","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T03:30:03Z","timestamp":1672889403000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparative analysis of the liver\u2010protective effects of raw and stir\u2010fried semen of <scp><i>Hovenia dulcis<\/i><\/scp> in rats via gas chromatography\u2013mass spectrometry\u2013based serum metabolomic profiling and chemometrics"],"prefix":"10.1002","volume":"37","author":[{"given":"Pan","family":"Lv","sequence":"first","affiliation":[{"name":"Clinical Laboratory Yongkang First People\u2019s Hospital Affiliated to Hangzhou Medical College  Yongkang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Zhu","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiyan","family":"Lv","sequence":"additional","affiliation":[{"name":"Clinical Laboratory Yongkang First People\u2019s Hospital Affiliated to Hangzhou Medical College  Yongkang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Bao","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Science Zhejiang University of Technology  Hangzhou 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