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A psoriasis\u2010form mouse model established using imiquimod (IMQ) was used to evaluate the anti\u2010psoriatic effects of PK. The serum samples were analyzed by high\u2010resolution nuclear magnetic resonance (<jats:sup>1<\/jats:sup>H NMR)\u2010based metabonomics. Nine amino acids were further quantitatively analyzed by ultra\u2010performance liquid chromatography\/quadrupole time\u2010of\u2010flight mass spectrometry (UPLC\/Q\u2010TOF MS). This study suggested that PK treatment markedly attenuated IMQ\u2010induced psoriasis in a dose\u2010dependent manner. <jats:sup>1<\/jats:sup>H NMR\u2010based multivariate trajectory analysis revealed that PK had a certain regression effect on eight differential metabolites. The quantitative results showed that PK could significantly regulate the serum levels of alanine, histidine and arginine to healthy control levels. The anti\u2010psoriasis mechanism of PK may be associated with the restoration of the disturbance in the amino acid metabolism, energy metabolism and lipid metabolism and so on. Quantitative results further confirmed that amino acid metabolism play an key role in the pathogenesis of psoriasis. Our investigation provided a holistic view of PK for intervention psoriasis and provided the scientific information <jats:italic>in vivo<\/jats:italic> about a clinical value of PK for psoriasis.<\/jats:p>","DOI":"10.1002\/bmc.5598","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T18:29:55Z","timestamp":1675880995000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolomics strategy of Pikang oral liquid in the treatment of psoriasis"],"prefix":"10.1002","volume":"37","author":[{"given":"Huiyun","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Hangzhou Third People\u2019s Hospital, Affiliated Hangzhou Dermatology Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baogang","family":"Xie","sequence":"additional","affiliation":[{"name":"College of medicine 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