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According to our previous study, oroxylin A (OA) could effectively protect ovariectomized (OVX)\u2010osteoporotic mice from bone loss; however, its therapeutic targets are still unclear. From a metabolomic perspective, we studied serum metabolic profiles to discover potential biomarkers and OVX\u2010related metabolic networks, which could assist us to comprehend the impact of OA on OVX. Five metabolites were identified as biomarkers associated with 10 related metabolic pathways, including phenylalanine, tyrosine and tryptophan biosynthesis, and phenylalanine, tryptophan and glycerophospholipid metabolism. After OA treatment, the expression of multiple biomarkers changed, with lysophosphatidylcholine (18:2) being a major significantly regulated biomarker. Our study demonstrated that OA's effects on OVX are probably related to the regulation of phenylalanine, tyrosine and tryptophan biosynthesis. Our findings explain the role of OA against PMOP in terms of metabolism and pharmacology and provide a pharmacological foundation for OA treatment of PMOP.<\/jats:p>","DOI":"10.1002\/bmc.5609","type":"journal-article","created":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T22:43:56Z","timestamp":1677019436000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["UPLC\/Q\u2010TOF\u2013MS\u2010based metabolomics evaluate the efficacy of oroxylin A against postmenopausal osteoporosis"],"prefix":"10.1002","volume":"37","author":[{"given":"Yansi","family":"Xian","sequence":"first","affiliation":[{"name":"Guangxi Key Laboratory of Regenerative Medicine, Orthopaedics Trauma and Hand Surgery The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi China"},{"name":"Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co\u2010constructed by the 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