{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T06:56:22Z","timestamp":1779173782864,"version":"3.51.4"},"reference-count":60,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,18]],"date-time":"2023-04-18T00:00:00Z","timestamp":1681776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["IFP23UQU4310387DSR000"],"award-info":[{"award-number":["IFP23UQU4310387DSR000"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Olanzapine (OLZ) is an antipsychotic agent and is a thienobenzodiazepine derivative. It is used either in combination with other drugs like carbamazepine, simvastatin, and clozapine or as a single drug. The present work is mainly focused on various approaches for OLZ analysis in bulk drugs as well as on their pharmaceutical formulations. It is also focused on various bioanalytical methods used for analysis. Our survey showed that many analytical techniques were carried out using UV spectrophotometry, MS, LC\u2013MS\/MS techniques, and chromatographic techniques like HPLC and high\u2010performance thin layer chromatography in both bulk and solid dosage forms. Bioanalytical techniques were also performed using human plasma or serum. The analysis was carried out either for a single drug or for a combination of drugs. This review shows the rate of use of the different methodologies for OLZ analysis. A considerable amount of information was collected and utilized for the strategies.<\/jats:p>","DOI":"10.1002\/bmc.5632","type":"journal-article","created":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T15:54:12Z","timestamp":1680018852000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A review of various analytical methods for the estimation of olanzapine: An antipsychotic drug"],"prefix":"10.1002","volume":"37","author":[{"given":"Reka","family":"S.","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Saveetha Institute of Medical and Technical Sciences (SIMATS) Saveetha College of Pharmacy  Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afsana","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics School of Pharmaceutical Education and Research, Jamia Hamdard  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waleed H.","family":"Almalki","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Umm Al\u2010Qura University  Makkah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0890-769X","authenticated-orcid":false,"given":"Prashant","family":"Kesharwani","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics School of Pharmaceutical Education and Research, Jamia Hamdard  New Delhi India"},{"name":"University Institute of Pharma Sciences Chandigarh University  Mohali Punjab India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4249-7962","authenticated-orcid":false,"given":"Punniyakoti Veeraveedu","family":"Thanikachalam","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Saveetha Institute of Medical and Technical Sciences (SIMATS) Saveetha College of Pharmacy  Chennai India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtusci.2014.03.007"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.JICS.2021.100215"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/BMC.4468"},{"issue":"3","key":"e_1_2_10_5_1","first-page":"23","article-title":"Optimized and validated spectrophotometric method for the determination of olanzapine in pharmaceutical formulations using 1, 2, \u2010Naphthoquinone\u20104\u2010Sulphonate (NQS)","volume":"4","author":"Ali A. 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