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In this study, we explored the prototypes and metabolites of GSBXD in rat plasma and urine using UHPLC\u2013Q\u2010TOF\/MS technology. A total of 82 GSBXD\u2010related xenobiotic bioactive components (38 prototypes and 44 metabolites) were confirmed or tentatively characterized, including 32 prototypes and 29 metabolites in plasma, and 25 prototypes and 29 metabolites in urine. The results showed that the bioactive components absorbed <jats:italic>in vivo<\/jats:italic> mainly contained diterpenoids, triterpenoids, flavonoids and monoterpene glycosides. Both phase I reactions (methylation, reduction, demethylation, hydrolysis, hydroxylation and oxidation) and phase II reactions (glucuronidation and sulfation) were involved in the metabolism of GSBXD <jats:italic>in vivo<\/jats:italic>. This study will provide a foundation for the quality control, pharmacological study and clinical application of GSBXD.<\/jats:p>","DOI":"10.1002\/bmc.5653","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T06:02:50Z","timestamp":1681365770000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Metabolite profiles of Gansuibanxia decoction in rat plasma and urine by UHPLC\u2010Q\u2010TOF\/MS analysis"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8445-5747","authenticated-orcid":false,"given":"Yue","family":"Cui","sequence":"first","affiliation":[{"name":"School of Pharmacy Jilin Medical University  Jilin PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmiao","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Jilin Medical University  Jilin PR China"},{"name":"School of Pharmacy Yanbian University  Yanji PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Pharmacy Jilin Medical University  Jilin PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phyplu.2021.100206"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2019.02.034"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2013.06.004"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2019.113029"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2019.121767"},{"key":"e_1_2_8_7_1","first-page":"66","article-title":"Analysis of terpenoids in Kansui stir\u2010baked with vinegar by UPHLC\u2010Q\u2010TOF\u2010MS","volume":"34","author":"Gao 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