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This study investigated the potential mechanisms underlying the anti\u2010hyperlipidemic effects of <jats:italic>L. bulbifera<\/jats:italic> using an integrated strategy based on metabolomics and network pharmacology methods that were established to investigate the potential mechanism of anti\u2010hyperlipidemia effect of <jats:italic>L. bulbifera<\/jats:italic>. First, the therapeutic effects of <jats:italic>L. bulbifera<\/jats:italic> on body weight reduction and biochemical indices were assessed. Next, 18 significant metabolites distinguishing the control and model groups were identified based on serum metabolomics and multivariate analyses. Then, a compound\u2013target network was constructed by linking <jats:italic>L. bulbifera<\/jats:italic> and hyperlipidemia using network pharmacology. Three metabolic pathways involved in treating hyperlipidemia were identified. Finally, five crucial targets were selected by constructing a bionetwork starting from the compounds and ending in the metabolites. This study established an integrated strategy based on metabolomics coupled with network pharmacology and revealed the mechanism underlying the protective effects of <jats:italic>L. bulbifera<\/jats:italic> against hyperlipidemia for the first time.<\/jats:p>","DOI":"10.1002\/bmc.5707","type":"journal-article","created":{"date-parts":[[2023,7,27]],"date-time":"2023-07-27T00:46:20Z","timestamp":1690418780000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Elucidating the mechanisms underlying the anti\u2010hyperlipidemic effects of <i>Laportea bulbifera<\/i> using integrated serum metabolomics and network pharmacology"],"prefix":"10.1002","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5603-8663","authenticated-orcid":false,"given":"Qingxin","family":"Shi","sequence":"first","affiliation":[{"name":"College of Pharmacy Hubei University of Chinese Medicine  Wuhan 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