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In this study, high\u2010performance liquid chromatography\u2013quadrupole\/time\u2010of\u2010flight mass spectrometry (HPLC\u2013Q\u2010TOF\u2013MS\/MS) was applied to characterize the overall chemical composition of CLDM. A total of 93 ingredients were characterized, including 25 flavonoids, 20 organic acids, 11 saponins, nine terpenoids, seven tannins and 21 other compounds. Then network pharmacology was applied to predict the potential bioactive components, target genes and signaling pathways of CLDM in improving ALI. Additionally, molecular docking was performed to demonstrate the interaction between the active ingredients and the disease targets. Finally, animal experiments further confirmed that CLDM significantly inhibits pulmonary inflammation, pulmonary edema and oxidative stress in lipopolysaccharide\u2010induced ALI mice by inhibiting the PI3K\u2013AKT signaling pathway. 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