{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:44:24Z","timestamp":1790401464345,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T00:00:00Z","timestamp":1691971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100016299","name":"Al-Ahliyya Amman University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100016299","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic wounds have become a major concern for healthcare systems, as they have been related to diabetic foot ulcers, venous leg ulcers and pressure ulcers. Oleuropein is an active compound that is extracted from olive leaves and it has the ability to reduce injury to tissues owing to its antioxidant effect, hence improving wound healing. The poor pharmacokinetics of oleuropein have limited its use clinically. This work is aimed toward studying the impact of PEGylated and non\u2010PEGylated nanoliposomes loaded with oleuropein, as a carrier model, on wound\u2010healing activity. The thin film hydration method was used to compose PEGylated and non\u2010PEGylated liposomes, both loaded with oleuropein. The results indicated that each free, PEGylated and non\u2010PEGylated composition was within the limit of optimum nanoliposome characterization. The results showed that non\u2010PEGylated compositions produced higher efficiency in encapsulation (47.09\u2009\u00b1\u00a010.06%) than the PEGylated ones (20.97\u2009\u00b1\u00a010.52%). The PEG\u2010nanoliposomes loaded with oleuropein (PEG\u2010oleu) had mean size, charge and polydispersity index of 129.35\u2009nm, \u22129.55 mV and 0.1010, respectively. The scratch assay results proved that PEGylated liposomal compositions have a more rapid wound\u2010healing activity than non\u2010PEGylated ones at different time intervals at 0, 2, 24 and 28\u2009h.<\/jats:p>","DOI":"10.1002\/bmc.5716","type":"journal-article","created":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T00:10:30Z","timestamp":1692058230000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Preparation, characterization and wound\u2010healing effect of PEGylated nanoliposomes loaded with oleuropein"],"prefix":"10.1002","volume":"37","author":[{"given":"Rand","family":"Alquraishi","sequence":"first","affiliation":[{"name":"Pharmacological and Diagnostic Research Centre, Faculty of Pharmacy Al\u2010Ahliyya Amman University  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Al\u2010samydai","sequence":"additional","affiliation":[{"name":"Pharmacological and Diagnostic Research Centre, Faculty of Pharmacy Al\u2010Ahliyya Amman University  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4097-6991","authenticated-orcid":false,"given":"Khaldun M.","family":"Al Azzam","sequence":"additional","affiliation":[{"name":"Pharmacological and Diagnostic Research Centre, Faculty of Pharmacy Al\u2010Ahliyya Amman University  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moath","family":"Alqaraleh","sequence":"additional","affiliation":[{"name":"Pharmacological and Diagnostic Research Centre, Faculty of Pharmacy Al\u2010Ahliyya Amman University  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2635-3619","authenticated-orcid":false,"given":"Lidia","family":"Al\u2010Halaseh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy Mutah University  Al\u2010Karak Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa","family":"Sanabrah","sequence":"additional","affiliation":[{"name":"Pharmacological and Diagnostic Research Centre, Faculty of Pharmacy Al\u2010Ahliyya Amman University  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha N.","family":"Abu Hajleh","sequence":"additional","affiliation":[{"name":"Department of Cosmetic Science, Pharmacological and Diagnostic Research Centre, Faculty of Allied Medical Sciences Al\u2010Ahliyya Amman University  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arwa","family":"Al Khatib","sequence":"additional","affiliation":[{"name":"Pharmacological and Diagnostic Research Centre, Faculty of Pharmacy Al\u2010Ahliyya Amman University  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walhan","family":"Alsaher","sequence":"additional","affiliation":[{"name":"Cell Therapy Center the University of Jordan  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u2010Sayed","family":"Negim","sequence":"additional","affiliation":[{"name":"School of Materials Science and Green Technologies Kazakh\u2010British Technical University  Almaty Kazakhstan"},{"name":"School of Petroleum Engineering Satbayev University  Almaty Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Khleifat","sequence":"additional","affiliation":[{"name":"Department of Biology Mutah University  Al\u2010Karak Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14441"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.579536"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.5812\/jjnpp.114568"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2021-0197"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13113995"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9ra05636j"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.13005\/bpj\/1985"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpc.2019.01.002"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3791\/56825"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/wound.2021.0026"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym13071027"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-020-02877-x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S101900"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1021\/acscentsci.6b00371"},{"key":"e_1_2_9_16_1","unstructured":"Jakucs C.(2020).Wound healing research: The need for grants is widespread.https:\/\/blog.wcei.net\/2020\/10\/wound-healing-research-the-need-for-grantsis-widespread(accessed July 10 2023)."},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-021-04972-2"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2016.05.074"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2022.132470"},{"key":"e_1_2_9_20_1","first-page":"8","article-title":"Recovery and stability of oleuropein and other phenolic compounds during extraction and processing of olive (Olea europaea L.) leaves","volume":"6","author":"Malik N. 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