{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T02:16:34Z","timestamp":1767924994141,"version":"3.49.0"},"reference-count":55,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073988"],"award-info":[{"award-number":["82073988"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Biomedical Chromatography"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Huangqi Jianzhong Tang (HQJZ) is effective for treating chronic atrophic gastritis (CAG). The present study was carried out to reveal the mechanism of HQJZ in CAG rats. The metabolism and microbial composition of the cecal contents in CAG rats were analyzed through the integration of an untargeted metabolomic approach using ultra\u2010high\u2010performance liquid chromatography coupled with the quadrupole\u2013time of flight mass spectrometry (UHPLC\u2013QTOF\u2013MS) and 16S rRNA gene sequencing, respectively. Finally, MetOrigin analyses were performed to explore the relationship between differential metabolites and intestinal flora. The results showed that HQJZ could significantly regulate metabolic disorders, especially conjugated acid metabolites. 16S rRNA gene sequencing analysis illustrated that HQJZ decreased the abundance of <jats:italic>Acetobacter<\/jats:italic>, <jats:italic>Desulfovibrio<\/jats:italic>, <jats:italic>Escherichia<\/jats:italic>, and <jats:italic>Shigella<\/jats:italic>. MetOrigin metabolite traceability analysis showed that the six bile acids associated with HQJZ efficacy included three bacteria\u2013host cometabolites, which were involved in the primary bile acid biosynthesis pathway. Research presented here confirmed that conjugated bile acid metabolism was key to the treatment of CAG by HQJZ and correlates strongly with <jats:styled-content style=\"fixed-case\"><jats:italic>Bacteroides acidifaciens<\/jats:italic><\/jats:styled-content> and <jats:styled-content style=\"fixed-case\"><jats:italic>Prevotella copri<\/jats:italic><\/jats:styled-content>. These findings provide new insights into the mechanisms to explain the efficacy of HQJZ.<\/jats:p>","DOI":"10.1002\/bmc.5721","type":"journal-article","created":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T17:03:43Z","timestamp":1692637423000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Huangqi Jianzhong Tang treats chronic atrophic gastritis rats by regulating intestinal flora and conjugated bile acid metabolism"],"prefix":"10.1002","volume":"37","author":[{"given":"Hui","family":"Zhang","sequence":"first","affiliation":[{"name":"Modern Research Center for Traditional Chinese Medicine, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Shanxi University  Taiyuan Shanxi China"},{"name":"Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province  Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingyue","family":"Huang","sequence":"additional","affiliation":[{"name":"Modern Research Center for Traditional Chinese Medicine, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Shanxi University  Taiyuan Shanxi China"},{"name":"Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province  Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guohong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Shanxi Traditional Chinese Medicine Hospital  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9829-0605","authenticated-orcid":false,"given":"Yuetao","family":"Liu","sequence":"additional","affiliation":[{"name":"Modern Research Center for Traditional Chinese Medicine, the Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education Shanxi University  Taiyuan Shanxi China"},{"name":"Key Laboratory of Effective Substances Research and Utilization in TCM of Shanxi Province  Taiyuan Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-01183-8"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.7501\/j.issn.0253-2670.2020.19.001"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12544"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i18.2834"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(80)90075-9"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2016.09.044"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.01.071"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.13862\/j.cnki.cn43-1446\/r.2015.12.039"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.13344\/j.microbiol.china.140778"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1472-765x.1997.00180.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11010013"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anaerobe.2017.12.013"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)37599-4"},{"key":"e_1_2_10_15_1","first-page":"964","article-title":"Rapid identification of chemical constituents in Huanqi Jianzhong Tang by UHPLC coupled with hybrid quadrupole\u2010orbitrap MS","volume":"52","author":"Hu Y. H.","year":"2017","journal-title":"Acta Pharmacologica Sinica"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i29.8787"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i25.8092"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640616644142"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-019-02020-6"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10213"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl18398"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/82_2012_303"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-305178"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X21500130"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.05.023"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1615\/JEnvironPatholToxicolOncol.2018026839"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.4103\/sjg.SJG_573_16"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.4754"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemolab.2017.03.005"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9AY00156E"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.13457\/j.cnki.jncm.2018.10.019"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/den.12030"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2011.05039.x"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(93)77454-8"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2015.04.004"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1005-7072.2008.03.008"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2047-9"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197706)39:6<2533::aid-cncr2820390634>3.0.co;2-x"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-022-04278-2"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.11.025"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i1.5"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9638963"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1212782"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-014-9860-0"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2015.09.013"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajp.22880"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/72.1.96"},{"issue":"7","key":"e_1_2_10_48_1","first-page":"16","article-title":"Modified Huangqi Jianzhong decoction in the treatment of 40 cases of gastroesophageal reflux disease","volume":"17","author":"Wang G. H.","year":"2004","journal-title":"Gansu Traditional Chinese Medicine"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202200263"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/878164"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.16448\/j.cjtcm.2022.1237"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.09-71"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.42"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/IMT2.10"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.4795"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.01.009"}],"container-title":["Biomedical Chromatography"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bmc.5721","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T21:00:31Z","timestamp":1760043631000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/bmc.5721"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,17]]},"references-count":55,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["10.1002\/bmc.5721"],"URL":"https:\/\/doi.org\/10.1002\/bmc.5721","archive":["Portico"],"relation":{},"ISSN":["0269-3879","1099-0801"],"issn-type":[{"value":"0269-3879","type":"print"},{"value":"1099-0801","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8,17]]},"assertion":[{"value":"2023-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e5721"}}